用于内分泌相关肿瘤靶向治疗的表面功能化纳米材料系统:最新进展回顾。
Surface functionalized nanomaterial systems for targeted therapy of endocrine related tumors: a review of recent advancements.
发表日期:2024 Dec
作者:
Limei Liu, Miao Yang, Ziyang Chen
来源:
DRUG DELIVERY
摘要:
多学科技术在内分泌相关癌症治疗中的应用对于发挥多学科优势、协调一致消除肿瘤至关重要。由于癌细胞的恶性特征,它们具有对化疗和放疗等传统治疗产生耐药性的能力。然而,尽管努力加强结果预测,患有内分泌相关恶性肿瘤的个体的总体生存率仍然相当低。因此,研究创新的治疗策略势在必行。治疗策略的最新进展为各种内分泌肿瘤的治疗提供了新方法。本文探讨了纳米药物输送技术的进步以及利用纳米材料通过靶向治疗精确治疗癌症。这篇综述对联合给药策略在甲状腺癌、肾上腺肿瘤和胰腺癌治疗中的潜力进行了全面分析。本研究的目的是更深入地了解当前的治疗方法,刺激新药DDS的开发,并提高这些疾病患者的治疗效果。通过将合成或天然物质植入纳米颗粒中,可以显着改善癌细胞对药物的细胞内摄取,从而大大减少内分泌恶性肿瘤的发展。
The application of multidisciplinary techniques in the management of endocrine-related cancers is crucial for harnessing the advantages of multiple disciplines and their coordinated efforts in eliminating tumors. Due to the malignant characteristics of cancer cells, they possess the capacity to develop resistance to traditional treatments such as chemotherapy and radiotherapy. Nevertheless, despite diligent endeavors to enhance the prediction of outcomes, the overall survival rate for individuals afflicted with endocrine-related malignancy remains quite miserable. Hence, it is imperative to investigate innovative therapy strategies. The latest advancements in therapeutic tactics have offered novel approaches for the therapy of various endocrine tumors. This paper examines the advancements in nano-drug delivery techniques and the utilization of nanomaterials for precise cancer cures through targeted therapy. This review provides a thorough analysis of the potential of combined drug delivery strategies in the treatment of thyroid cancer, adrenal gland tumors, and pancreatic cancer. The objective of this study is to gain a deeper understanding of current therapeutic approaches, stimulate the development of new drug DDS, and improve the effectiveness of treatment for patients with these diseases. The intracellular uptake of pharmaceuticals into cancer cells can be significantly improved through the implantation of synthetic or natural substances into nanoparticles, resulting in a substantial reduction in the development of endocrine malignancies.