探讨基于扩散的虚拟磁共振弹性成像（vMRE）在术前预测肝细胞癌（HCC）复发的能力，并研究潜在的相关组织病理学特征。2015年8月至2016年12月期间，患者接受了术前MRI检查招募 DWI 序列（b 值：200,1500 s/mm2）。计算了 HCC 的 ADC 值和基于扩散的虚拟剪切模量 (μdiff)，并分析了 MR 形态特征。 Cox比例风险模型用于识别与肿瘤复发相关的危险因素。建立术前放射学模型和术后模型（包括病理特征）来预测肝切除术后肿瘤复发。本研究共纳入 87 例经手术证实的孤立性 HCC 患者。 35名患者（40.2%）在肝切除术后发现肿瘤复发。术前模型包括较高的μdiff和电晕增强，而术后模型包括较高的μdiff、微血管侵犯和组织学肿瘤分级。这些因素被确定为无复发生存期 (RFS) 的重要预后因素（所有 p<0.05）。 μdiff 值 > 2.325 kPa 的 HCC 患者肝切除后 5 年 RFS 比 μdiff 值 ≤ 2.325 kPa 的患者较差 (p < 0.001)。此外，较高的μdiff值与CK19的表达（3.95±±2.37 vs. 3.15±±1.77，p=±0.017）和高Ki-67标记指数（4.22±±1.63 vs. 2.72±±2.12，p=±0.001）相关。 ). 的与 CK19 和 Ki-67 标记指数表达相关的 μdiff 值可能预测 HCC 患者肝切除术后的 RFS。© 2024。作者。

To explore the capability of diffusion-based virtual MR elastography (vMRE) in the preoperative prediction of recurrence in hepatocellular carcinoma (HCC) and to investigate the underlying relevant histopathological characteristics.Between August 2015 and December 2016, patients underwent preoperative MRI examination with a dedicated DWI sequence (b-values: 200,1500 s/mm2) were recruited. The ADC values and diffusion-based virtual shear modulus (μdiff) of HCCs were calculated and MR morphological features were also analyzed. The Cox proportional hazards model was used to identify the risk factors associated with tumor recurrence. A preoperative radiologic model and postoperative model including pathological features were built to predict tumor recurrence after hepatectomy.A total of 87 patients with solitary surgically confirmed HCCs were included in this study. Thirty-five patients (40.2%) were found to have tumor recurrence after hepatectomy. The preoperative model included higher μdiff and corona enhancement, while the postoperative model included higher μdiff, microvascular invasion, and histologic tumor grade. These factors were identified as significant prognostic factors for recurrence-free survival (RFS) (all p < 0.05). The HCC patients with μdiff values > 2.325 kPa showed poorer 5-year RFS after hepatectomy than patients with μdiff values ≤ 2.325 kPa (p < 0.001). Moreover, the higher μdiff values was correlated with the expression of CK19 (3.95 ± 2.37 vs. 3.15 ± 1.77, p = 0.017) and high Ki-67 labeling index (4.22 ± 1.63 vs. 2.72 ± 2.12, p = 0.001).The μdiff values related to the expression of CK19 and Ki-67 labeling index potentially predict RFS after hepatectomy in HCC patients.© 2024. The Author(s).