中国及各省1990-2019年消化系统疾病负担：2019年全球疾病负担研究结果

Burden of digestive system diseases in China and its provinces during 1990-2019: Results of the 2019 Global Disease Burden Study

CHINESE MEDICAL JOURNAL

影响因子:7.3

分区:医学2区 / 医学：内科2区

发表日期:2024 Sep 20

作者: Zhiyuan Cheng, Tinglu Wang, Yunfei Jiao, Jinlei Qi, Xun Zhang, Siwei Zhou, Lei Xin, Rong Wan, Maigeng Zhou, Zhaoshen Li, Luowei Wang

DOI: 10.1097/CM9.0000000000003277

摘要

评估消化系统疾病的影响对于制定有效的预防策略至关重要。然而，关于中国消化系统疾病负担的全面报道尚缺。本研究旨在提供1990至2019年中国及各省消化系统疾病负担和趋势的概览。本横断面研究利用2019年全球疾病负担研究数据，估算中国各省1990至2019年的消化系统疾病的发病率、死亡率、残疾调整生命年（DALYs）、生活质量损失年、生命丧失年及负担变化。分析主要关注亚疾病分布特征、时间趋势、年龄分布和性别差异，并将各省的年龄标准化DALYs与社会人口指标（SDI）预期水平进行比较。结果显示：2019年，中国消化系统疾病病例达4.992亿例，导致死亡155万多例。胃癌、结直肠癌和食管癌是与死亡率和DALYs关系最紧密的前三种疾病。慢性肝病和肝硬化、胃食管反流病及胆囊胆道疾病为患病率最高的疾病。男性40岁以上，胃癌风险显著增加，导致男女间负担差异明显。随着SDI提高，消化系统疾病相关的DALYs在中国及各省呈下降趋势。我们的研究强调了DALYs与SDI之间的负相关关系。

Abstract

Evaluating the impact of digestive system diseases is vital for devising effective prevention strategies. However, comprehensive reports on the burden of digestive system diseases in China are lacking. Our study aimed to provide an overview of the burden and trends of digestive system diseases from 1990 to 2019 in China and its provinces.This cross-sectional study utilized the Global Disease Burden Study 2019 to estimate the incidence, mortality rate, disability-adjusted life years (DALYs), years of life disability, years of life lost, and changes in the burden of digestive diseases across Chinese provinces from 1990 to 2019. The analysis of disease burden primarily examines the characteristics of sub-disease distribution, time trends, age distribution, and sex distribution. Additionally, we compared provincial age-standardized DALYs for digestive diseases with the expected rates based on the socio-demographic index (SDI).In 2019, there were 499.2 million cases of digestive system diseases in China, resulting in 1,557,310 deaths. Stomach cancer, colon and rectal cancer, and esophageal cancer are the top three diseases associated with mortality and DALY related to digestive system diseases. Meanwhile, cirrhosis and other chronic liver diseases, gastroesophageal reflux disease, and gallbladder and biliary diseases are the top three kinds of diseases with the highest prevalence among digestive system diseases. The risk of gastric cancer sharply increases among men after the age of 40 years, leading to a significant disparity in burden between men and women. As the SDI increased, the DALYs associated with digestive system diseases in China and its provinces showed a downward trend.Our study highlights the inverse correlation between DALYs associated with digestive system diseases and the SDI.