评估消化系统疾病的影响对于制定有效的预防策略至关重要。然而，缺乏关于中国消化系统疾病负担的综合报告。我们的研究旨在概述 1990 年至 2019 年中国及其省份消化系统疾病的负担和趋势。这项横断面研究利用 2019 年全球疾病负担研究来估计发病率、死亡率、伤残调整寿命1990-2019年中国31个省份DALYs、失能年数、生命损失年数以及消化系统疾病负担变化情况。疾病负担分析主要考察分疾病分布特征、时间趋势、年龄分布、性别分布。此外，我们将消化系统疾病的省级年龄标准化伤残调整生命年与基于社会人口统计指数 (SDI) 的预期比率进行了比较。2019 年，中国消化系统疾病病例为 4.992 亿，导致 1,557,310 人死亡。胃癌、结直肠癌、食道癌是与消化系统疾病相关的死亡率和伤残调整生命年(DALY)排名前三位的疾病。同时，肝硬化等慢性肝脏疾病、胃食管反流病、胆囊胆道疾病是消化系统疾病中发病率最高的前三类疾病。男性40岁以后患胃癌的风险急剧增加，导致男女负担显着差异。随着SDI的增加，中国及各省份与消化系统疾病相关的DALY呈下降趋势。我们的研究强调了与消化系统疾病相关的DALY与SDI之间的负相关性，为公共卫生官员提供了宝贵的见解，可以帮助公共卫生官员估计该领域的疾病负担。版权所有 © 2024 中华医学会，由 Wolters Kluwer, Inc. 根据 CC-BY-NC-ND 许可制作。

Evaluating the impact of digestive system diseases is vital for devising effective prevention strategies. However, comprehensive reports on the burden of digestive system diseases in China are lacking. Our study aimed to provide an overview of the burden and trends of digestive system diseases from 1990 to 2019 in China and its provinces.This cross-sectional study utilized the Global Disease Burden Study 2019 to estimate the incidence, mortality rate, disability-adjusted life years (DALYs), years of life disability, years of life lost, and changes in the burden of digestive diseases across 31 Chinese provinces from 1990 to 2019. The analysis of disease burden primarily examines the characteristics of sub-disease distribution, time trends, age distribution, and sex distribution. Additionally, we compared provincial age-standardized DALYs for digestive diseases with the expected rates based on the socio-demographic index (SDI).In 2019, there were 499.2 million cases of digestive system diseases in China, resulting in 1,557,310 deaths. Stomach cancer, colon and rectal cancer, and esophageal cancer are the top three diseases associated with mortality and DALY related to digestive system diseases. Meanwhile, cirrhosis and other chronic liver diseases, gastroesophageal reflux disease, and gallbladder and biliary diseases are the top three kinds of diseases with the highest prevalence among digestive system diseases. The risk of gastric cancer sharply increases among men after the age of 40 years, leading to a significant disparity in burden between men and women. As the SDI increased, the DALYs associated with digestive system diseases in China and its provinces showed a downward trend.Our study highlights the inverse correlation between DALYs associated with digestive system diseases and the SDI, providing valuable insights that can assist public health officials in the estimation of the disease burden in this area.Copyright © 2024 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license.