紫杉烷类药物因其优异的抗肿瘤作用，在临床上用于多种癌症的治疗。然而，目前临床使用的注射剂中所含的表面活性剂可能对机体产生严重的毒副作用，因此有必要开发新的剂型。阳离子脂质体因其优先靶向肿瘤新生血管的优势而被广泛应用于抗肿瘤研究，但仅靶向肿瘤血管系统抗肿瘤并不一定能获得良好的效果。恶性肿瘤代表着复杂的生态系统，肿瘤微环境中的肿瘤相关巨噬细胞（TAM）和肿瘤内皮细胞（TEC）在肿瘤生长中发挥着至关重要的作用。因此，考虑到以唾液酸（SA）作为靶向材料能够实现TAM和TEC的主动靶向，阳离子纳米制剂优先靶向肿瘤部位新生血管的潜力，以及紫杉烷类药物多西他赛优异的抗肿瘤作用。 DOC），本研究选择唾液酸-胆固醇偶联（SA-CH）作为靶向材料，制备用于肿瘤治疗的DOC阳离子脂质体（DOC-SAL）。研究结果表明，与普通DOC制剂相比，DOC-SAL在肿瘤组织中的药物蓄积最强，能够有效减少TAMs的定植，抑制肿瘤细胞的增殖，具有最好的抑瘤作用。影响。此外，DOC-SAL能够通过调节细胞因子来改善肿瘤的内部微环境。综上所述，该给药系统具有良好的抗肿瘤作用，为肿瘤治疗提供了新的选择。

Taxane drugs are clinically used for the treatment of many types of cancers due to their excellent antitumor effects. However, the surfactants contained in the injections currently used in the clinic may have serious toxic side effects on the organism, making it necessary to develop new dosage forms. Cationic liposomes have been widely used in antitumor research because of their advantage of preferentially targeting tumor neovascularization, but antitumor by targeting tumor vasculature alone does not necessarily provide good results. Malignant tumors represent complex ecosystems, tumor-associated macrophages (TAMs) and tumor endothelial cells (TECs) in the tumor microenvironment play crucial roles in tumor growth. Therefore, given the ability to achieve active targeting of TAMs and TECs by using sialic acid (SA) as a targeting material, the potential of cationic nanoformulations to preferentially target neovascularization at the tumor site, and the excellent antitumor effects of the taxane drugs docetaxel (DOC), in the present study, sialic acid-cholesterol coupling (SA-CH) was selected as a targeting material to prepare a DOC cationic liposome (DOC-SAL) for tumor therapy. The results of the study showed that DOC-SAL had the strongest drug accumulation in tumor tissues compared with the common DOC formulations, and was able to effectively reduce the colonization of TAMs, inhibit the proliferation of tumor cells, and have the best tumor-suppressing effect. In addition, DOC-SAL was able to improve the internal microenvironment of tumors by modulating cytokines. In summary, this drug delivery system has good anti-tumor effects and provides a new option for tumor therapy.