细胞外囊泡 (EV) 是细胞激活、细胞损伤或凋亡过程中释放的纳米级脂质双层囊泡。它们携带核酸、蛋白质和脂质，促进细胞间通讯并激活靶细胞中的信号通路。在非小细胞肺癌（NSCLC）中，EVs可能通过调节免疫反应、促进上皮-间质转化和促进血管生成来促进肿瘤生长和转移，同时可能导致对化疗药物的耐药性。液体活检中的 EV 可作为早期癌症检测和诊断的非侵入性生物标志物。由于 EV 尺寸小、固有的分子运输特性和出色的生物相容性，EV 还可作为 NSCLC 治疗中的天然药物输送载体。© 2024 Wu 和 Chen。

Extracellular vesicles (EVs) are nanoscale lipid bilayer vesicles released during cell activation, cellular damage, or apoptosis. They carry nucleic acids, proteins, and lipids facilitating intercellular communication and activate signaling pathways in target cells. In non-small cell lung cancer (NSCLC), EVs may contribute to tumor growth and metastasis by modulating immune responses, facilitating epithelial-mesenchymal transition, and promoting angiogenesis, while potentially contributing to resistance to chemotherapy drugs. EVs in liquid biopsies serve as non-invasive biomarkers for early cancer detection and diagnosis. Due to their small size, inherent molecular transport properties, and excellent biocompatibility, EVs also act as natural drug delivery vehicles in NSCLC therapy.© 2024 Wu and Chen.