慢性免疫介导的炎症，称为炎症性肠病（IBD），会显着影响胃肠系统。虽然 IBD 的确切病因仍然难以捉摸，但广泛的研究表明，一系列病理生理学途径和免疫病理学机制可能作为潜在因素发挥重要作用。间充质干细胞（MSC）在开发针对各种医疗状况的新型治疗方法方面显示出巨大的潜力。然而，一些间充质干细胞被发现表现出致瘤特性，这限制了它们的医学治疗潜力。细胞外囊泡 (EV)、旁分泌因子在 MSC 带来的治疗益处中发挥着至关重要的作用。 EV 由蛋白质、microRNA 和脂质组成，有助于促进细胞间通讯。由于易于维护，并且免疫原性和致瘤性降低，EV 已成为全细胞治疗的一种新的、令人兴奋的选择。这篇综述全面评估了最近关于人脐带间充质干细胞 (hUC-MSC) 衍生的 EV 作为一种潜在的 IBD 治疗的临床前研究。它全面解决了各种疾病的关键方面，包括糖尿病、癌症、皮肤损伤、神经系统疾病、心血管问题、肝肾疾病以及骨骼相关疾病。版权所有 © 2024 Din、Wan、Chu、Zhou、Yan 和 Xu。

The chronic immune-mediated inflammatory condition known as inflammatory bowel disease (IBD) significantly affects the gastrointestinal system. While the precise etiology of IBD remains elusive, extensive research suggests that a range of pathophysiological pathways and immunopathological mechanisms may significantly contribute as potential factors. Mesenchymal stem cells (MSCs) have shown significant potential in the development of novel therapeutic approaches for various medical conditions. However, some MSCs have been found to exhibit tumorigenic characteristics, which limit their potential for medical treatments. The extracellular vesicles (EVs), paracrine factors play a crucial role in the therapeutic benefits conferred by MSCs. The EVs consist of proteins, microRNAs, and lipids, and are instrumental in facilitating intercellular communication. Due to the ease of maintenance, and decreased immunogenicity, tumorigenicity the EVs have become a new and exciting option for whole cell treatment. This review comprehensively assesses recent preclinical research on human umbilical cord mesenchymal stem cell (hUC-MSC)-derived EVs as a potential IBD therapy. It comprehensively addresses key aspects of various conditions, including diabetes, cancer, dermal injuries, neurological disorders, cardiovascular issues, liver and kidney diseases, and bone-related afflictions.Copyright © 2024 Din, Wan, Chu, Zhou, Yan and Xu.