在这里，我们报道了一种具有锍部分的全新生物活性聚合物，它具有诱导免疫原性细胞死亡（ICD）的能力，用于抗癌治疗。优化的聚锍具有广泛的有效抗癌活性和显着的选择性。深入的机理研究表明，该聚合物通过膜破坏机制对癌细胞发挥细胞毒性作用。这进一步引发了大量与损伤相关的分子模式的释放，有效触发 ICD 并导致全身抗癌免疫反应。值得注意的是，该化合物在 B16-F10 黑色素瘤模型中表现出显着的抑制肿瘤生长的功效。此外，它表现出强大的免疫记忆效应，在再攻击模型和肺转移肿瘤模型中均能有效抑制肿瘤复发和转移。据我们所知，该研究代表了阳离子聚锍的开创性出口，不仅展示了其针对原发性肿瘤的显着安全性和功效，而且还展示了其激活长期免疫记忆的独特能力。

Here we report a brand-new bioactive polymer featuring sulfonium moieties that exhibits the capability of inducing immunogenic cell death (ICD) for anticancer therapy. The optimized polysulfonium presents a wide spectrum of potent anticancer activity and remarkable selectivity. In-depth mechanistic studies reveal that the polymer exerts its cytotoxic effects on cancer cells through a membrane-disrupting mechanism. This further initiates the release of a plethora of damage-associated molecular patterns, effectively triggering ICD and resulting in systemic anticancer immune responses. Notably, the compound demonstrated significant efficacy in suppressing tumor growth in the B16-F10 melanoma tumor model. Furthermore, it exhibits robust immune memory effects, effectively suppressing tumor recurrence and metastasis in both the rechallenge model and the lung metastatic tumor model. To the best of our knowledge, the study represents the pioneering exportation of cationic polysulfoniums, showcasing not only their remarkable safety and efficacy against primary tumors but also their unique ability in activating long-term immune memory.