胸壁切除术适用于多种疾病，最常见的适应症是原发性肋骨和软组织肿瘤、转移性病变或肺和纵隔肿瘤的局部侵袭性生长。切除阶段后，必须确定胸壁重建方法，以恢复结构功能、保留肺生物力学、减少残留胸膜腔、肺疝的可能性并保护胸腔内器官。本研究的主要目的是探讨使用 Codubix 材料进行胸壁切除重建的结果。这项回顾性多中心研究纳入了 2019 年至 2023 年接受胸壁肿瘤切除并随后进行 Codubix 肋骨内置假体重建的 22 名患者。四家医疗机构参与研究：P.A.莫斯科赫尔岑癌症研究所、斯维尔德洛夫斯克地区肿瘤医院、莫罗佐夫儿童城市临床医院和卡卢加地区肿瘤医院。纳入标准为存在原发性和继发性胸壁肿瘤、切除超过 2 根肋骨、切除肋弓和胸骨。中位年龄为 60 岁（48-66），11 名（50%）患者女性和 11 名（50%）男性。胸壁肉瘤、转移灶和肺癌手术分别为 9 例（40.9%）、4 例（18.2%）和 3 例（13.6%）。切除肋骨中位数为 3 根（2-4 根），最多为 7 根。9 例（40.9%）患者进行了胸骨切开术，77.7% 的患者进行了胸骨体或胸骨柄次全切除。 14 例（63.6%）患者进行了联合切除。 21 名 (95.5%) 患者实现了肿瘤根治性切除 (R0)。 9 名患者（40.9%）出现并发症，其中 3 名患者（33.3%）出现肌间血清肿，其次为胸水，2 名患者（22.2%），双侧肺炎、急性呼吸衰竭和术后谵妄，1 名患者（11.1%） ）每个病人。一名患者因术后伤口感染而移除了 Codubix 板。未达到中位总生存率和无复发生存率，1 年无复发生存率为 63.9%，总生存率为 86.8%。使用 Codubix 材料进行重建可以获得令人满意的功能和美容结果，其特点是并发症低率和良好的自适应特性。

Chest wall resection is performed for a variety of diseases, for primary rib and soft tissue tumors, metastatic lesions, or locally invasive growth of lung and mediastinal tumors being the most common indications. Following the resection phase, it is essential to determine the method of chest wall reconstruction that will restore the structural function, preserve pulmonary biomechanics, reduce the likelihood of residual pleural space, pulmonary hernia, and protect intrathoracic organs. The main objective of this study is to investigate the outcomes of chest wall resection with reconstruction using Codubix material.This retrospective multicenter study included 22 patients who underwent chest wall tumor resection with subsequent Codubix rib endoprosthesis reconstruction from 2019 to 2023. Four medical institutions participated in the study: P.A. Herzen Moscow Cancer Research Institute, Sverdlovsk Regional Oncology Hospital, Morozov Children's City Clinical Hospital and Kaluga Regional Oncology Hospital. Inclusion criteria were the presence of chest wall tumors, both primary and secondary, removal of more than 2 ribs, resection of the rib arch and the sternum.The median age was 60 years (48-66), 11 (50%) patients were females and 11 (50%) males. Operations for chest wall sarcoma, metastatic lesions, and lung cancer were performed in 9 (40.9%), 4 (18.2%), and 3 (13.6%) patients, respectively. The median number of removed ribs was 3 (2-4), with a maximum of 7. Sternotomy was performed in 9 (40.9%) patients, and subtotal resection of the body or handle of the sternum was carried out in 77.7%. Combined resections were performed in 14 (63.6%) patients. Radical tumor removal (R0) was achieved in 21 (95.5%) patients. Complications were observed in 9 (40.9%) patients, with intermuscular seroma being the most common in three (33.3%), followed by hydrothorax in 2 (22.2%), bilateral pneumonia, acute respiratory failure, and postoperative delirium in 1 (11.1%) patient each. One patient had the Codubix plate removed due to postoperative wound infection. The median overall and recurrence-free survival was not reached, and the 1-year recurrence-free survival was 63.9%, with an overall survival of 86.8%.Reconstruction with Codubix material allows for satisfactory functional and cosmetic results, characterized by a low complication rate and good adaptive properties.