QTc 间期延长可能导致潜在致命的心律失常。危险因素之一是延长 QTc 的药物，包括血液肿瘤患者常用的一些抗真菌药物。尚未在该患者群体中研究针对高危患者的筛查工具。我们的目的是评估接受全身抗真菌治疗的血液肿瘤患者中五种 QTc 风险评分的敏感性和特异性。数据取自内部研究数据库，包括成人血液肿瘤患者接受全身抗真菌治疗。回顾性收集了 12 个月的有关延长 QTc 的药物、QTc 延长的危险因素和心电图 (ECG) 的数据。根据 Tisdale、Vandael、Berger、Bindraban 和 Aboujaoude 计算 QTc 风险评分及其敏感性和特异性。在评估期间，77 名患者接受了全身抗真菌药物治疗，进行了 187 次治疗。关于治疗次数，中位年龄为 56 岁（IQR 44-68），41%（77 岁）为女性，平均开出 3 种延长 QTc 的药物（范围 0-6）。开始抗真菌治疗后 3-11 天，有 45 次 (24%) 的治疗发作可进行心电图检查，其中 22 次显示 QTc 延长。对于这 45 次治疗，风险评分的敏感性和特异性计算如下：Tisdale 86%/22%、Vandael 91%/35%、Berger 32%/83%、Bindraban 50%/78%、Aboujaoude 14%/ 87%。根据 Tisdale 和 Vandael 的 QTc 风险评分显示出对所研究患者群体的风险分层足够的敏感性。相比之下，由于敏感性较差，Berger、Bindraban 和 Aboujaoude 的风险评分不能被认为是合适的。© 2024。作者。

QTc interval prolongation can result in potentially lethal arrhythmias. One risk factor is QTc-prolonging drugs, including some antifungals often used in hemato-oncology patients. Screening tools for patients at risk have not yet been investigated in this patient population.Our aim was to evaluate the sensitivity and specificity of five QTc risk scores in hemato-oncology patients receiving systemic antifungal therapy.Data were retrieved from an internal study database including adult hemato-oncology patients prescribed systemic antifungal therapy. Data on QTc-prolonging medication, risk factors for QTc prolongation, and electrocardiograms (ECG) were collected retrospectively for a period of 12 months. The QTc risk scores according to Tisdale, Vandael, Berger, Bindraban, and Aboujaoude as well as their sensitivity and specificity were calculated.During the evaluated period, 77 patients were prescribed systemic antifungals resulting in 187 therapy episodes. Regarding therapy episodes, median age was 56 years (IQR 44-68), 41% (77) were female, and a median of 3 QTc-prolonging drugs were prescribed (range 0-6). ECGs were available for 45 (24%) of the therapy episodes 3-11 days after initiation of the antifungal therapy, 22 of which showed QTc prolongation. Regarding these 45 therapy episodes, sensitivity and specificity of the risk scores were calculated as follows: Tisdale 86%/22%, Vandael 91%/35%, Berger 32%/83%, Bindraban 50%/78%, Aboujaoude 14%/87%.The QTc risk scores according to Tisdale and Vandael showed sufficient sensitivity for risk stratification in the studied patient population. In contrast, risk scores according to Berger, Bindraban, and Aboujaoude cannot be considered suitable due to poor sensitivity.© 2024. The Author(s).