传统的全身癌症治疗常常会引起许多不良事件。然而，在实体瘤中发现过度表达的叶酸受体为靶向化疗铺平了道路。叶酸（FA）是这些受体的配体，经常与化疗药物联合使用以提高其疗效。碳纳米管已成为一种多功能且有前途的方法，用于传递这些叶酸共轭纳米系统，确保将治疗剂靶向传递至癌细胞。当 FA 偶联的纳米管解离时，它们会在恶性细胞内释放载药纳米管，从而减少脱靶效应。这些纳米管还可用于联合疗法，产生协同效应。本综述旨在全面收集并严格评估使用 FA 共轭纳米载体提供治疗的最新方法。此外，它旨在增强我们对这种方法所涉及的相关化学和生化途径的理解。

Conventional systemic cancer therapy often causes numerous adverse events. However, discovering overexpressed folate receptors in solid tumors has paved the way for targeted chemotherapy. Folic acid (FA), a ligand for these receptors, is frequently combined with chemotherapeutic drugs to improve their effectiveness. Carbon nanotubes have emerged as a versatile and promising method for delivering these folate-conjugated nano-systems, ensuring targeted delivery of therapeutic agents to cancerous cells. When FA-conjugated nanotubes dissociate, they release the drug-loaded nanotubes inside the malignant cells, reducing off-target effects. These nanotubes can also be used for combination therapies, producing synergistic effects. This review aims to comprehensively gather and critically evaluate the latest methods for delivering therapeutics using FA-conjugated nanovehicles. Additionally, it seeks to enhance our comprehension of the pertinent chemistry and biochemical pathways involved in this approach.