三阴性乳腺癌（TNBC）是乳腺癌的一种亚型，预后最差且缺乏特定的治疗靶点。为了在 TNBC 部位实现准确的“货物”递送，我们构建了一种新型仿生纳米特洛伊木马，将化疗与基因疗法结合起来，以增强 TNBC 治疗。简而言之，我们首先将含有二硒键的有机二氧化硅部分引入介孔二氧化硅纳米颗粒（MON）的框架中，从而赋予所获得的MONSe在肿瘤内氧化还原条件下的生物降解性。随后，阿霉素（Dox）和治疗性miR-34a被加载到MONSe中，从而实现化疗和基因治疗的结合。经过同源肿瘤细胞膜包被后，最终的同源肿瘤细胞仿生纳米特洛伊木马（即MONSe@Dox@miR-34a@CM）可以以隐身方式选择性地进入肿瘤细胞。值得注意的是，这样的纳米平台不仅可以协同消除肿瘤，还可以在体外和体内抑制乳腺癌干样细胞（BCSC）的增殖。凭借同源肿瘤细胞膜促进瘤内积聚、优异的生物降解性和协同基因化疗的整合，我们的仿生纳米载体为未来 TNBC 的治愈带来了巨大的希望。

Triple-negative breast cancer (TNBC) is a subtype of breast cancer that carries the worst prognosis and lacks specific therapeutic targets. To achieve accurate "cargos" delivery at the TNBC site, we herein constructed a novel biomimetic nano-Trojan horse integrating chemotherapy with gene therapy for boosting TNBC treatment. Briefly, we initially introduce the diselenide-bond-containing organosilica moieties into the framework of mesoporous silica nanoparticles (MONs), thereby conferring biodegradability to intratumoral redox conditions in the obtained MONSe. Subsequently, doxorubicin (Dox) and therapeutic miR-34a are loaded into MONSe, thus achieving the combination of chemotherapy and gene-therapy. After homologous tumor cell membrane coating, the ultimate homologous tumor cell-derived biomimetic nano-Trojan horse (namely, MONSe@Dox@miR-34a@CM) can selectively enter the tumor cells in a stealth-like fashion. Notably, such a nanoplatform not only synergistically eradicated the tumor but also inhibited the proliferation of breast cancer stem-like cells (BCSCs) in vitro and in vivo. With the integration of homologous tumor cell membrane-facilitated intratumoral accumulation, excellent biodegradability, and synergistic gene-chemotherapy, our biomimetic nanocarriers hold tremendous promise for the cure of TNBC in the future.