苹果酸酶 (ME) 是催化苹果酸氧化为丙酮酸和 NAD(P)H 的代谢酶。虽然研究人员已经很好地确定了 ME 在生物体中的生理代谢作用，但最近的研究揭示了 ME 与致癌之间的联系。这篇综述整理了 ME 促进癌症发生的分子机制的证据，包括转录调控、转录后调控、翻译后蛋白质修饰和蛋白质-蛋白质相互作用。此外，我们还强调了 ME 在重编程能量代谢、抑制衰老和调节肿瘤免疫微环境中的作用。我们还讨论了这些酶在介导肿瘤耐药性中的作用，以及开发针对 ME 的新型小分子抑制剂如何成为一种良好的治疗方法。通过本次综述的见解预计将提供对 ME 与癌症之间复杂关系的全面了解，同时促进未来对靶向 ME 在癌症管理中的潜在治疗应用的研究。版权所有 © 2024 作者。由 Elsevier B.V. 出版。保留所有权利。

Malic enzymes (MEs) are metabolic enzymes that catalyze the oxidation of malate to pyruvate and NAD(P)H. While researchers have well established the physiological metabolic roles of MEs in organisms, recent research has revealed a link between MEs and carcinogenesis. This review collates evidence of the molecular mechanisms by which MEs promote cancer occurrence, including transcriptional regulation, post-transcriptional regulation, post-translational protein modifications, and protein-protein interactions. Additionally, we highlight the roles of MEs in reprogramming energy metabolism, suppressing senescence, and modulating the tumor immune microenvironment. We also discuss the involvement of these enzymes in mediating tumor resistance and how the development of novel small-molecule inhibitors targeting MEs might be a good therapeutic approach. Insights through this review are expected to provide a comprehensive understanding of the intricate relationship between MEs and cancer, while facilitating future research on the potential therapeutic applications of targeting MEs in cancer management.Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.