组织驻留记忆 T (TRM) 细胞与癌症生存呈正相关，但这种关系背后的抗肿瘤机制尚不清楚。这篇综述协调了这些观察结果，总结了 T 细胞免疫监视的概念、基本 TRM 细胞生物学以及 TRM 细胞在癌症和免疫治疗结果中的作用的临床观察。我们还讨论了利用 TRM 表型细胞进行患者诊断、分期和治疗的新兴策略。当前的挑战突出，包括缺乏标准化的 T 细胞命名法以及我们对 T 细胞标记物与潜在肿瘤生物学之间关系的了解有限。现有研究结果被纳入该领域的摘要，同时强调未来研究的机会。版权所有 © 2024 Elsevier Inc. 保留所有权利。

Tissue-resident memory T (TRM) cells positively correlate with cancer survival, but the anti-tumor mechanisms underlying this relationship are not understood. This review reconciles these observations, summarizing concepts of T cell immunosurveillance, fundamental TRM cell biology, and clinical observations on the role of TRM cells in cancer and immunotherapy outcomes. We also discuss emerging strategies that utilize TRM-phenotype cells for patient diagnostics, staging, and therapy. Current challenges are highlighted, including a lack of standardized T cell nomenclature and our limited understanding of relationships between T cell markers and underlying tumor biology. Existing findings are integrated into a summary of the field while emphasizing opportunities for future research.Copyright © 2024 Elsevier Inc. All rights reserved.