肿瘤基质在肿瘤进展中起着至关重要的作用，细胞外基质、肿瘤细胞和基质细胞之间的相互作用共同影响肿瘤进展和治疗药物的疗效。目前，利用肿瘤基质成分进行药物输送是一个值得注意的策略。许多基于肿瘤基质成分设计的靶向给药系统正在进入临床试验。因此，本文对肿瘤基质在靶向药物递送系统的进步中的功能进行了彻底的检查。一种方法是使用肿瘤基质成分进行靶向药物递送，其中包括某些具有固有靶向能力的基质成分，如HA、层粘连蛋白，以及同源靶向基质细胞。另一种方法需要直接关注肿瘤基质成分以重塑肿瘤基质并促进药物输送。这些药物输送系统在更有效的癌症治疗策略方面表现出巨大的潜力，例如精确靶向、增强渗透、改善安全性和生物相容性。最终，这些药物输送系统的部署可以加深我们对肿瘤基质的理解以及相应药物输送系统的先进开发。版权所有 © 2024。由 Elsevier B.V. 出版。

The tumor stroma plays a crucial role in tumor progression, and the interactions between the extracellular matrix, tumor cells, and stromal cells collectively influence tumor progression and the efficacy of therapeutic agents. Currently, utilizing components of the tumor stroma for drug delivery is a noteworthy strategy. A number of targeted drug delivery systems designed based on tumor stromal components are entering clinical trials. Therefore, this paper provides a thorough examination of the function of tumor stroma in the advancement of targeted drug delivery systems. One approach is to use tumor stromal components for targeted drug delivery, which includes certain stromal components possessing inherent targeting capabilities like HA, laminin, along with targeting stromal cells homologously. Another method entails directly focusing on tumor stromal components to reshape the tumor stroma and facilitate drug delivery. These drug delivery systems exhibit great potential in more effective cancer therapy strategies, such as precise targeting, enhanced penetration, improved safety profile, and biocompatibility. Ultimately, the deployment of these drug delivery systems can deepen our comprehension of tumor stroma and the advanced development of corresponding drug delivery systems.Copyright © 2024. Published by Elsevier B.V.