有人认为尿路感染 (UTI) 与膀胱癌 (BC) 的延迟诊断有关。我们的目的是调查与 UTI 相关的诊断前治疗以及与 BC 诊断延迟的关系，这反映在诊断时的晚期疾病。我们使用了 BladderBaSe 2.0 的数据以及 BC 诊断前 3 年（2008-2019 年）与 UTI 相关的治疗数据。 ）对于 BC 患者与匹配的参考人群进行比较。我们在 BC 队列中研究了 UTI 治疗与诊断时更晚期疾病之间的关联。我们使用广义有序逻辑回归来计算更晚期疾病的比值比 (OR) 作为有序结果：非肌肉侵袭性 BC (NMIBC)、肌肉侵袭性 BC (MIBC) 和转移性 BC (MBC)。包括 29 921 名 BC 患者和 149 467 名匹配的参考受试者。患者组中接受 UTI 治疗的个体比例高于相应参考组，其中 MIBC 和 MBC 亚组差异最大。接受至少一种 UTI 治疗与未接受治疗相比，发生更晚期疾病（MIBC 或 MBC）的风险的 OR 对于男性为 1.28（95% 置信区间 [CI] 1.19-1.37），对于女性为 1.42（95% CI 1.27-1.58） 。随着男女尿路感染治疗次数的增加，与更晚期疾病的风险相关性也随之增加。需要对尿路感染相关治疗与其他因素相结合的效果进行进一步研究，以确定 BC 诊断途径可能延迟的原因。我们发现对于膀胱癌患者来说，先前针对尿路感染的抗生素治疗与诊断时病情进展有关。需要进一步的研究来确定膀胱癌诊断可能延迟的原因。版权所有 © 2024 作者。由 Elsevier B.V. 出版。保留所有权利。

It has been suggested that urinary tract infections (UTIs) are associated with delayed diagnosis of bladder cancer (BC). Our aim was to investigate prediagnostic treatments related to UTI and the relation to BC diagnostic delay, reflected by advanced disease at diagnosis.We used data from the BladderBaSe 2.0 with data of treatments related to UTI up to 3 yr before BC diagnosis (2008-2019) for BC patients in comparison to a matched reference population. We investigated the association between UTI treatments and more advanced disease at diagnosis in the BC cohort. We used generalized ordered logistic regression to calculate odds ratios (ORs) for more advanced disease as an ordered outcome: non-muscle-invasive BC (NMIBC), muscle-invasive BC (MIBC), and metastatic BC (MBC).The study population included 29 921 BC patients and 149 467 matched reference subjects. The proportions of individuals receiving UTI treatment were higher in the patient groups than in the corresponding reference groups, with the greatest differences observed for the MIBC and MBC subgroups. The OR for the risk of more advanced disease (MIBC or MBC) with at least one UTI treatment versus none was 1.28 (95% confidence interval [CI] 1.19-1.37) for men and 1.42 (95 % CI 1.27-1.58) for women. The association to risk of more advanced disease increased with the number of UTI treatments for both sexes.Further studies on the effects of treatments related to UTI in combination with other factors are needed to identify reasons for possible delays in the BC diagnostic pathway.We found that for patients with bladder cancer, previous antibiotic treatment for a urinary tract infection was linked to more advanced disease at diagnosis. Further studies are needed to identify reasons for possible delays in the diagnosis of bladder cancer.Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.