实验室或医院地点之间的医学样本运输通常通过机动地面运输进行。由于城市环境中交通拥堵的加剧，无人机运输已成为快速运输样品的有吸引力的替代方案。根据 CLSI 指南和 ISO 15189 标准，必须彻底验证这种运输类型对样本完整性和实验室测试性能的影响。对 36 名健康志愿者的血液样本和加标细菌的尿液样本进行 20-40 分钟的处理在对它们进行分析并与地面上的同类进行比较之前，先进行无人机飞行。评估了对 30 项常规生化和血液学参数、免疫血液学测试以及流式细胞术和分子测试的稳定性的影响。对血型分型、流式细胞术淋巴细胞亚群测试以及多拷贝不透明相关蛋白 (Opa) 的稳定性没有临床相关影响细菌 DNA 中的基因以及人外周血细胞中 Abelson 鼠白血病病毒癌基因同源物 1 (abl) 管家基因的数量都被观察到。对于 30 个生物化学和血液学参数中的三个，发现了统计学上的显着差异：γ-谷氨酰转移酶 (γ-GT)、平均红细胞血红蛋白 (MCH) 和血小板计数。然而，仅对钾和乳酸脱氢酶 (LDH) 产生临床相关影响。多旋翼无人机运输可用于医学样本运输，对大多数测试参数没有影响，包括流式细胞术和分子分析，但例外对钾和 LDH 的临床影响有限。© 2024 Walter de Gruyter GmbH，柏林/波士顿。

Transportation of medical samples between laboratories or hospital sites is typically performed by motorized ground transport. Due to the increased traffic congestions in urban environments, drone transportation has become an attractive alternative for fast shipping of samples. In accordance with the CLSI guidelines and the ISO 15189 standard, the impact of this transportation type on sample integrity and performance of laboratory tests must be thoroughly validated.Blood samples from 36 healthy volunteers and bacterial spiked urine samples were subjected to a 20-40 min drone flight before they were analyzed and compared with their counterparts that stayed on the ground. Effects on stability of 30 routine biochemical and hematological parameters, immunohematology tests and flow cytometry and molecular tests were evaluated.No clinically relevant effects on blood group typing, flow cytometry lymphocyte subset testing and on the stability of the multicopy opacity-associated proteins (Opa) genes in bacterial DNA nor on the number of Abelson murine leukemia viral oncogene homolog 1 (abl) housekeeping genes in human peripheral blood cells were seen. For three of the 30 biochemistry and hematology parameters a statistically significant difference was found: gamma-glutamyl transferase (gamma-GT), mean corpuscular hemoglobin (MCH) and thrombocyte count. A clinically relevant effect however was only seen for potassium and lactate dehydrogenase (LDH).Multi-rotor drone transportation can be used for medical sample transportation with no effect on the majority of the tested parameters, including flow cytometry and molecular analyses, with the exception of a limited clinical impact on potassium and LDH.© 2024 Walter de Gruyter GmbH, Berlin/Boston.