口腔癌是我国最常见的癌症之一，严重威胁中国人民的生命和健康。分析2006-2021年中国口腔癌死亡率和疾病负担的变化趋势和差异，为口腔癌的预防和控制提供参考。口腔癌年度死亡数据来源于中国死亡监测数据库。采用年龄标准化死亡率（ASMR）、年度百分比变化（APC）和平均APC（AAPC）来分析死亡率趋势。采用预期寿命损失（LLE）和寿命损失年数（YLL）评估疾病负担。2006年至2021年，口腔癌总体ASMR略有下降（AAPC： - 0.97％；95％CI： - 1.89％， - 0.04%），女性中也观察到类似的趋势（AAPC： - 1.22%；95% CI： - 1.89%， - 0.55%）。男性的ASMR每年比女性高2.31-3.16倍。 2006 年至 2021 年，男性和女性口腔癌引起的 LLE 中位数分别为 0.05 年、0.06 年和 0.03 年。从2006年到2021年，总体（AAPC： - 1.31％，95％CI： - 2.24％ ~  - 0.37％）和女性（AAPC： - 1.63％，95％CI： - 2.30％）标准化YLL率有所下降~  - 0.95%）。 2006-2011年城市ASMR比农村高1.02-1.28倍，但2018-2021年城市比农村低0.85-0.97倍。城市疾病负担高于农村2006年的情况相反，而2021年的情况则相反。中国的性别和地区之间存在严重的健康差距和趋势差异。男性和农村人口需要重点关注主要影响因素的针对性干预措施。© 2024。作者。

Oral cancer is one of the most common cancers in China and seriously threaten life and health of Chinese people. We analysed the trends and disparities of oral cancer mortality rates and the disease burden of oral cancer in China from 2006 to 2021 to provide a reference for its prevention and control.Annual death data for oral cancer was gleaned from the China Death Surveillance Database. The age-standardized mortality rate (ASMR), annual percentage change (APC), and average APC (AAPC) were used to analyze the trend of mortality. Loss of life expectancy (LLE) and years of life lost (YLL) were adopted to assess disease burden.From 2006 to 2021, the overall ASMR of oral cancer lightly declined (AAPC: - 0.97%; 95% CI: - 1.89%, - 0.04%), and the similar trend was observed among females (AAPC: - 1.22%; 95% CI: - 1.89%, - 0.55%). The ASMR of males was 2.31-3.16 times higher than that of females per year. The median of LLE for overall, males and females caused by oral cancer from 2006 to 2021 were 0.05, 0.06 and 0.03 years, respectively. There was a decrease of standardized YLL rate from 2006 to 2021 for overall (AAPC: - 1.31%, 95% CI: - 2.24% ~  - 0.37%) and for female (AAPC: - 1.63%, 95% CI: - 2.30% ~  - 0.95%). ASMR in urban areas was 1.02-1.28 times higher than that in rural areas from 2006 to2011, but 0.85-0.97 times lower in urban areas than that in rural areas from 2018 to 2021. The disease burden was higher in urban areas than in rural areas in 2006, whereas the reverse was observed in 2021.There are severe health gaps and disparities in trends between sexes and different areas in China. Males and rural populations need to be focused on targeted interventions for the main influencing factors.© 2024. The Author(s).