大约5%至10%的软组织肉瘤属于滑膜肉瘤（SSs），这是一种罕见的恶性肿瘤，起源于软组织，分化不明确，主要影响青少年和年轻人。本研究的目的是利用监测、流行病学和最终结果（SEER）数据库评估儿童 SS 的最新生存率以及影响生存的危险因素。年龄、性别、种族、SEER 分期、手术、放疗、化疗、 SEER 数据库中收集偏侧性、SS 部位和生存时间，用于生存和预后因素分析。根据不同因素，采用Kaplan-Meier法得出总生存曲线和癌症特殊生存曲线。还构建了多变量 Cox 回归模型和预测列线图。共有 130 名患者参加了该研究。总生存分析中，年龄（P=0.01）、男性（P=0.04）、未手术（P<0.01）、化疗（P<0.01）、原发肿瘤部位为软组织（P=0.02）、远处转移SEER 分期（P<0.01）与 SS 儿童预后较差相关。多因素分析显示化疗和SEER分期较远是不良预后的独立指标。专门的癌症生存分析也得出了类似的结果。使用列线图预测儿童 SS 的预后，并使用校准曲线根据实际观察到的生存结果验证列线图预测。 总之，化疗和较差的 SEER 分期与较差的总体生存率和癌症特殊生存率相关。列线图能够预测 1 年、5 年和 10 年总生存率，并与实际观察到的结果具有良好的一致性。2024 年转化儿科。版权所有。

Roughly 5% to 10% of soft tissue sarcomas fall under the category of synovial sarcomas (SSs), a rare and malignant tumor originating from soft tissues with unclear differentiation, primarily affecting teenagers and young adults. The goal of this study was to assess the latest survival rates for SS of children and the risk factors affecting survival using the Surveillance, Epidemiology and End Results (SEER) database.Age, sex, race, SEER stage, surgery, radiation, chemotherapy, laterality, site of SS, and survival time were collected in the SEER database for survival and prognostic factor analysis. The overall survival curves and cancer special survival were obtained by Kaplan-Meier according to different factors. A multivariate Cox regression model and a predictive nomogram have also been constructed.A total of 130 patients were enrolled in the study. In the overall survival analysis, age (P=0.01), male (P=0.04), no surgery (P<0.01), chemotherapy (P<0.01), primary tumor site in soft tissue (P=0.02), and in distant of SEER stage (P<0.01) were associated with a worse prognosis in children with SS. Multivariate analysis showed that chemotherapy and in distant of SEER stage were independent indicators of unfavorable prognosis. A similar result was released in the specialized cancer survival analysis. A nomogram was used to predict the prognosis of SS in children and a calibration curve was used to validate the nomogram prediction against the actual observed survival outcomes.In summary, chemotherapy, and worse SEER stage were associated with poorer overall and cancer special survivals. Nomogram was able to predict the probability of 1-, 5- and 10-year overall survivals and showed good consistency with the actual observed outcomes.2024 Translational Pediatrics. All rights reserved.