白血病是一种造血干细胞恶性克隆性疾病。药物治疗是白血病的核心治疗策略，但目前的治疗药物存在生物利用度低、不良反应大、静脉给药不方便等缺陷。靶向治疗可以将药物与细胞上特定的致癌位点相结合，杀死癌细胞，同时避免对正常细胞造成损害，已逐渐成为白血病治疗的主流方法。此外，纳米药物输送系统可以通过控制尺寸和通过修饰策略有针对性地优化药物输送来显着提高药物疗效。因此，基于纳米材料的白血病靶向治疗具有巨大的研究价值和应用前景。本文首先概述了目前白血病的治疗策略，然后综述了前沿的白血病靶向治疗纳米材料，包括有机纳米材料（主要是碳基纳米材料、脂质材料、聚合物等）和无机纳米材料（主要是贵金属纳米材料）。金属纳米颗粒、磁性纳米颗粒、中空介孔材料等）。还简要回顾了靶向纳米材料治疗白血病的未来发展的挑战和前景。© 2024 作者。由爱思唯尔有限公司出版

Leukemia is a kind of hematopoietic stem cell malignant clonal disease. Drug therapy is the core treatment strategy for leukemia, but the current therapeutic drugs have defects such as low bioavailability, large adverse reactions and inconvenient intravenous administration. Targeted therapy can combine drugs with specific carcinogenic sites on cells to kill cancer cells and avoid damage to normal cells, which has gradually become the mainstream method of leukemia treatment. In addition, nanomedicine delivery systems can significantly improve drug efficacy through controlled size and targeted optimization of drug delivery by modification strategies. Therefore, the targeted treatment of leukemia based on nanomaterials has great research value and application prospect. This paper gives an overview of the current therapeutic strategies for leukemia, and then reviews the cutting-edge targeted therapeutic nanomaterials for leukemia, including organic nanomaterials (mainly carbon-based nanomaterials, lipid materials, polymers, etc.) and inorganic nanomaterials (mainly noble metal nanoparticles, magnetic nanoparticles, hollow mesoporous materials, etc.). The challenges and prospects for the future development of targeted nanomaterials in the treatment of leukemia are also briefly reviewed.© 2024 The Authors. Published by Elsevier Ltd.