程序性细胞死亡（PCD）对于维持体内消化道的正常结构和功能起着至关重要的作用。幽门螺杆菌（H. pylori）感染是导致胃损伤的重要因素，促进Correa级联反应，加速胃炎向胃癌的转变。最近的研究表明，幽门螺杆菌感染期间，多个PCD信号通路异常激活，PCD功能障碍被认为有助于胃癌的发展并干扰治疗。随着PCD方面对H. pylori感染的研究不断深入，探索不同PCD途径中H. pylori与机体的相互作用机制可能成为未来治疗H. pylori感染及H. pylori的重要研究方向。相关胃癌。此外，能够抑制或诱导PCD的生物活性化合物可能作为治疗该疾病的关键要素。在这篇综述中，我们简要描述了PCD的过程，讨论了不同PCD信号通路之间的相互作用与H. pylori感染或H. pylori相关胃癌的机制，并总结了每个过程中可能发挥治疗作用的活性分子。在此过程中PCD通路，以期更全面地了解PCD在幽门螺杆菌感染中的作用。版权所有©2024 Lin，Liu，Lu，Zhai和Cheng。

Programmed cell death (PCD) plays a crucial role in maintaining the normal structure and function of the digestive tract in the body. Infection with Helicobacter pylori (H. pylori) is an important factor leading to gastric damage, promoting the Correa cascade and accelerating the transition from gastritis to gastric cancer. Recent research has shown that several PCD signaling pathways are abnormally activated during H. pylori infection, and the dysfunction of PCD is thought to contribute to the development of gastric cancer and interfere with treatment. With the deepening of studies on H. pylori infection in terms of PCD, exploring the interaction mechanisms between H. pylori and the body in different PCD pathways may become an important research direction for the future treatment of H. pylori infection and H. pylori-related gastric cancer. In addition, biologically active compounds that can inhibit or induce PCD may serve as key elements for the treatment of this disease. In this review, we briefly describe the process of PCD, discuss the interaction between different PCD signaling pathways and the mechanisms of H. pylori infection or H. pylori-related gastric cancer, and summarize the active molecules that may play a therapeutic role in each PCD pathway during this process, with the expectation of providing a more comprehensive understanding of the role of PCD in H. pylori infection.Copyright © 2024 Lin, Liu, Lu, Zhai and Cheng.