人们对与癌症诊断的配偶相关的自杀行为风险知之甚少。为了估计癌症患者的配偶自杀未遂和自杀死亡的风险。丹麦的这项全国性队列研究收集了 1986 年以来的基于登记的数据分析时间为2022年8月8日至2023年10月30日。随机选择配偶在1986年至2015年期间被诊断患有癌症的个人与配偶在同一时期未诊断出癌症的个人进行比较从一般人群中筛选，并按出生年份和性别进行匹配。配偶患有癌症诊断。自杀企图是通过丹麦国家患者登记册和丹麦精神病学中央研究登记册确定的，而自杀死亡是通过丹麦死亡原因登记册确定的，截至 2016 年。使用灵活的参数和 Cox 比例风险模型来估计癌症诊断患者配偶的自杀企图和自杀死亡的风险比 (HR) 和 95% CI。该研究包括 409338 名暴露者和 2046682 名暴露者未暴露个体（两组进入队列时的中位 [IQR] 年龄均为 63 [54-70] 岁； 55.4% 为女性）。在随访期间，确定了 2714 起暴露者自杀未遂事件（发病率 [IR]，每 100000 人年 62.6 起）和未暴露者中的 9994 起自杀未遂事件（IR，每 100000 人年 50.5 例），如下：暴露者中有 711 例自杀死亡（IR，每 10 万人年 16.3 例），未暴露者中有 2270 例自杀死亡（IR，每 10 万人年 11.4 例）。在整个随访过程中，观察到癌症患者的配偶自杀企图（HR，1.28；95% CI，1.23-1.34）和自杀死亡（HR，1.47；95% CI，1.35-1.60）的风险增加。在癌症诊断后的第一年，风险增加尤其显着，自杀企图的 HR 为 1.45（95% CI，1.27-1.66），自杀死亡的 HR 为 2.56（95% CI，2.03-3.22）。当癌症被诊断为晚期或配偶在癌症诊断后死亡时，自杀企图和自杀死亡的风险都会增加。这些研究结果表明，需要提高临床和社会意识，以预防患者配偶的自杀行为患有癌症，特别是在癌症诊断后的第一年。

Little is known about the risk of suicidal behavior in relation to having a spouse with a cancer diagnosis.To estimate the risk of suicide attempt and suicide death among spouses of patients with cancer.This nationwide cohort study in Denmark collected registry-based data from 1986 through 2016. Analyses were performed from August 8, 2022, to October 30, 2023. Individuals who had a spouse with a cancer diagnosed during 1986 to 2015 were compared with individuals whose spouse did not have a cancer diagnosis during the same period, randomly selected from the general population and matched by birth year and sex.Having a spouse with a cancer diagnosis.Suicide attempt was identified through the Danish National Patient Register and the Danish Psychiatric Central Research Register, whereas suicide death was identified through the Danish Causes of Death Register, through 2016. Flexible parametric and Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% CIs for suicide attempt and suicide death among spouses of patients with a cancer diagnosis.The study included 409 338 exposed individuals and 2 046 682 unexposed individuals (median [IQR] age at cohort entry for both groups, 63 [54-70] years; 55.4% women). During the follow-up, 2714 incident cases of suicide attempt among exposed individuals (incidence rate [IR], 62.6 per 100 000 person-years) and 9994 among unexposed individuals (IR, 50.5 per 100 000 person-years) were identified, as well as 711 cases of suicide death among the exposed individuals (IR, 16.3 per 100 000 person-years) and 2270 among the unexposed individuals (IR, 11.4 per 100 000 person-years). An increased risk of suicide attempt (HR, 1.28; 95% CI, 1.23-1.34) and suicide death (HR, 1.47; 95% CI, 1.35-1.60) was observed among spouses of patients with cancer throughout the follow-up. The increased risk was particularly notable during the first year after the cancer diagnosis, with an HR of 1.45 (95% CI, 1.27-1.66) for suicide attempt and 2.56 (95% CI, 2.03-3.22) for suicide death. There was a greater risk increase for both suicide attempt and suicide death when the cancer was diagnosed at an advanced stage or when the spouse died after the cancer diagnosis.These findings suggest a need for clinical and societal awareness to prevent suicidal behaviors among spouses of patients with cancer, particularly during the first year following the cancer diagnosis.