在本文中，展示了一种新型 U 形锥形空心纤维 (HCF) 表面等离子共振 (SPR) 生物传感器，其涂有 PtS2，用于早期胃癌 (GC) 诊断。该文章首次提出利用光纤SPR技术检测与胃癌风险相关的白细胞介素10（IL10）和白细胞介素1β（IL1β）。这里，通过锥形和U形结构的结合，有效提高了传感器的灵敏度。此外，为了进一步增强检测能力，利用二维材料PtS2来增加传感器的表面电场强度。同时，对锥度比、弯曲直径、金膜厚度等结构参数进行优化。最终，设计的传感器在 1.33-1.37 的折射率 (RI) 范围内实现了 13210 nm/RIU 的卓越灵敏度。该传感器表现出卓越的性能，检测 IL10 和 IL1β 生物标志物的灵敏度分别为 3.64 nm/(ng/ml) 和 7.46 nm/(ng/ml)，检测限 (LOD) 为 2.74 pg/ml和 1.33 pg/ml，并成功检测到胃癌患者血清中这些生物标志物的存在。总体而言，所提出的传感器在早期胃癌检测中表现出巨大的潜力，并推进了光纤 SPR 传感器在痕量生物检测中的应用。版权所有 © 2024 Elsevier B.V. 保留所有权利。

In this article, a novel U-tapered hollow-core fiber (HCF) surface plasmon resonance (SPR) biosensor coated with PtS2 for early-stage gastric carcinoma (GC) diagnosis was demonstrated. The article proposed the first investigation to detect Interleukin-10 (IL10) and Interleukin-1β (IL1β) which were associated with the risk of developing gastric carcinoma, using optical fiber SPR technology. Herein, the sensitivity of sensor was effectively improved through a combination of tapered and U-shaped structures. Additionally, to further enhance the detection capability, two-dimensional material PtS2 was utilized to increase the surface electric field intensity of the sensor. Simultaneously, optimization of structural parameters such as taper ratio, bending diameters, and Au film thickness was conducted. Ultimately, the designed sensor achieved a remarkable sensitivity of 13210 nm/RIU within the refractive index (RI) range of 1.33-1.37. The sensor demonstrated exceptional performance, achieving sensitivities of 3.64 nm/(ng/ml) and 7.46 nm/(ng/ml) for the detection of IL10 and IL1β biomarkers, respectively, along with limit of detection (LOD) of 2.74 pg/ml and 1.33 pg/ml, and successfully detecting the presence of these biomarkers in the serum of gastric cancer patients. Overall, the proposed sensor exhibits significant potential in early gastric cancer detection and advances the application of optical fiber SPR sensors in trace biodetection.Copyright © 2024 Elsevier B.V. All rights reserved.