癌细胞基于葡萄糖类似物的荧光探针吸收的新兴趋势：从基础研究到治疗
Emerging trends on the uptake of fluorescent probes based on glucose analogs by cancer cells: From basic studies to therapeutics
影响因子:5.10000
分区:医学3区 / 药学2区 医学：研究与实验3区
发表日期:2024 Oct 15
作者:
Rafaella B L Henrique, Ana L F Santos, Maria I A Pereira, Natália R M Santos, Goreti Pereira, Paulo E Cabral Filho, Adriana Fontes
摘要
癌细胞代谢，特别是以沃堡作用为特征，一直是有关葡萄糖类似物摄取机制的强烈研究的重点，开辟了诊断和治疗癌症疾病的观点。在这篇综述中，我们深入研究了癌症研究的不断发展的景观，以基于葡萄糖类似物的荧光探针为中心。这些类似物是由碳水化合物结构与官能团的修饰所产生的，在从疾病理解到治疗创新等应用中的多功能分子中脱颖而出，尤其是与荧光化合物结合使用。基于荧光的测定为生命科学中复杂生物学机制的启示提供了宝贵的贡献。这篇综述介绍了过去六年到2024年的精选研究，与使用基于葡萄糖的荧光探针有关，以研究其摄取概况以及用于治疗目的。我们认为，这些研究提供了有关葡萄糖类似物与癌细胞代谢之间复杂相互作用的见解，从而指导了未来的研究和该领域的临床应用。
Abstract
The cancer cell metabolism, notably characterized by the Warburg effect, has been the focus of intense investigation regarding the mechanisms of the uptake of glucose analogs, opening up perspectives for diagnosis and treatment of cancer disease. In this review, we delve into the ever-evolving landscape of cancer research, centering on fluorescent probes based on glucose analogs. These analogs, resulting from modifications in the carbohydrate structure with functional groups, have stood out as versatile molecules in applications ranging from disease comprehension to therapeutic innovation, especially when combined with fluorescent compounds. Fluorescence-based assays have provided valuable contributions to the revelation of complex biological mechanisms in life sciences. This review presents selected studies from about the past six years up to 2024 related to the use of glucose-based fluorescent probes, for the investigation of their uptake profile as well as for therapeutic purposes. We believe that these investigations offer insights into the intricate interaction between glucose analogs and cancer cell metabolism, guiding future research and clinical applications in this field.