癌细胞代谢，尤其以瓦尔堡效应为特征，一直是有关葡萄糖类似物摄取机制的深入研究的焦点，为癌症疾病的诊断和治疗开辟了前景。在这篇综述中，我们深入研究了癌症研究不断发展的前景，重点是基于葡萄糖类似物的荧光探针。这些类似物是通过用官能团对碳水化合物结构进行修饰而产生的，在从疾病理解到治疗创新的应用中作为多功能分子脱颖而出，特别是与荧光化合物结合时。基于荧光的检测为揭示生命科学中复杂的生物机制做出了宝贵的贡献。本综述介绍了从过去六年到 2024 年的精选研究，这些研究涉及使用基于葡萄糖的荧光探针来研究其摄取概况以及用于治疗目的。我们相信，这些研究可以深入了解葡萄糖类似物与癌细胞代谢之间复杂的相互作用，指导该领域的未来研究和临床应用。版权所有 © 2024。由 Elsevier Inc. 出版。

The cancer cell metabolism, notably characterized by the Warburg effect, has been the focus of intense investigation regarding the mechanisms of the uptake of glucose analogs, opening up perspectives for diagnosis and treatment of cancer disease. In this review, we delve into the ever-evolving landscape of cancer research, centering on fluorescent probes based on glucose analogs. These analogs, resulting from modifications in the carbohydrate structure with functional groups, have stood out as versatile molecules in applications ranging from disease comprehension to therapeutic innovation, especially when combined with fluorescent compounds. Fluorescence-based assays have provided valuable contributions to the revelation of complex biological mechanisms in life sciences. This review presents selected studies from about the past six years up to 2024 related to the use of glucose-based fluorescent probes for the investigation of their uptake profile as well as for therapeutic purposes. We believe that these investigations offer insights into the intricate interaction between glucose analogs and cancer cell metabolism, guiding future research and clinical applications in this field.Copyright © 2024. Published by Elsevier Inc.