基于葡萄糖类似物的荧光探针在癌细胞摄取的最新趋势：从基础研究到治疗应用
Emerging trends on the uptake of fluorescent probes based on glucose analogs by cancer cells: From basic studies to therapeutics
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影响因子:5.1
分区:医学3区 / 药学2区 医学：研究与实验3区
发表日期:2024 Oct 15
作者:
Rafaella B L Henrique, Ana L F Santos, Maria I A Pereira, Natália R M Santos, Goreti Pereira, Paulo E Cabral Filho, Adriana Fontes
DOI:
10.1016/j.lfs.2024.122978
摘要
癌细胞的代谢特征，尤以Warburg效应为代表，一直是研究葡萄糖类似物摄取机制的焦点，为癌症的诊断与治疗提供了新的视角。在本综述中，我们深入探讨了以葡萄糖类似物为基础的荧光探针的不断演进，强调其在从疾病理解到治疗创新中的多重应用，尤其是在结合荧光化合物后。荧光检测技术在生命科学中对揭示复杂生物机制发挥了重要作用。本文总结了过去六年左右到2024年关于葡萄糖基荧光探针的研究，内容涵盖其摄取特性及在治疗中的应用。我们相信，这些研究为理解葡萄糖类似物与癌细胞代谢的复杂相互作用提供了宝贵的见解，为未来的科研和临床应用指明了方向。
Abstract
The cancer cell metabolism, notably characterized by the Warburg effect, has been the focus of intense investigation regarding the mechanisms of the uptake of glucose analogs, opening up perspectives for diagnosis and treatment of cancer disease. In this review, we delve into the ever-evolving landscape of cancer research, centering on fluorescent probes based on glucose analogs. These analogs, resulting from modifications in the carbohydrate structure with functional groups, have stood out as versatile molecules in applications ranging from disease comprehension to therapeutic innovation, especially when combined with fluorescent compounds. Fluorescence-based assays have provided valuable contributions to the revelation of complex biological mechanisms in life sciences. This review presents selected studies from about the past six years up to 2024 related to the use of glucose-based fluorescent probes, for the investigation of their uptake profile as well as for therapeutic purposes. We believe that these investigations offer insights into the intricate interaction between glucose analogs and cancer cell metabolism, guiding future research and clinical applications in this field.