预后营养指数（PNI）和全身炎症免疫指数（SII）分别是营养状态和全身炎症反应的特征指标。然而，这些指标在临床上的综合作用尚不清楚。因此，利用SII-PNI评分预测局部晚期胃癌（LAGC）化疗后预后和肿瘤反应的实用性是本研究的主要关注点。我们回顾性分析了181例新辅助化疗后接受根治性切除的LAGC患者。一项前瞻性研究（NCT01516944）。我们根据肿瘤反应（AJCC/CAP 指南）将这些患者分为肿瘤消退等级 (TRG) 3 组和非 TRG3 组。在治疗前评估并确认 SII 和 PNI 的临界值。 SII-PNI值从0到2变化，其中2表示高SII（≥ 471.5）和低PNI（≤ 48.6），高SII或低PNI用1表示，两者都不用0表示，分别有51个和130个样本有TRG3和非TRG3肿瘤反应。具有 TRG3 的患者比没有 TRG3 的患者具有显着更高的 SII-PNI 评分 (p<<0.0001)。 SII-PNI 评分较高的患者预后较差 (p<<0.0001)。研究发现，SII-PNI 评分是总生存率（HR = 4.982，95%CI：1.890-10.234，p = 0.001）和无病生存率（HR = 4.763，95%CI：1.994-13.903）的独立预测因子。 ，p = 0.001）在多变量分析中。基于 SII-PNI 评分的低成本分层在预测 LAGC 肿瘤反应和预后方面的临床潜力和准确性是令人满意的。© 2024。作者。

The prognosis nutritional index (PNI) and the systemic inflammatory immunological index (SII) are characteristic indicators of the nutritional state and the systemic inflammatory response, respectively. However, there is an unknown combined effect of these indicators in the clinic. Therefore, the practicality of using the SII-PNI score to predict prognosis and tumor response of locally advanced gastric cancer (LAGC) following chemotherapy was the main focus of this investigation.We retrospectively analyzed 181 patients with LAGC who underwent curative resection after neoadjuvant chemotherapy in a prospective study (NCT01516944). We divided these patients into tumour regression grade(TRG) 3 and non-TRG3 groups based on tumor response (AJCC/CAP guidelines). The SII and PNI were assessed and confirmed the cut-off values before treatment. The SII-PNI values varied from 0 to 2, with 2 being the high SII (≥ 471.5) as well as low PNI (≤ 48.6), a high SII or low PNI is represented by a 1 and neither is represented by a 0, respectively.51 and 130 samples had TRG3 and non-TRG3 tumor responses respectively. Patients with TRG3 had substantially higher SII-PNI scores than those without TRG3 (p < 0.0001). Patients with greater SII-PNI scores had a poorer prognosis (p < 0.0001). The SII-PNI score was found to be an independent predictor of both overall survival (HR = 4.982, 95%CI: 1.890-10.234, p = 0.001) and disease-free survival (HR = 4.763, 95%CI: 1.994-13.903, p = 0.001) in a multivariate analysis.The clinical potential and accuracy of low-cost stratification based on SII-PNI score in forecasting tumor response and prognosis in LAGC is satisfactory.© 2024. The Author(s).