早发性胃癌（EOGC）的发病率持续上升，且病因复杂。这种增加可能归因于与晚发性胃癌（LOGC）相关的独特因素，包括遗传倾向、饮食因素、胃微生物群失调和高危病例筛查。这些因素共同导致癌症的发生。 EOGC 在临床病理学和分子特征方面与 LOGC 显着不同。此外，预后和临床管理也存在多种差异。本研究旨在系统回顾 EOGC 的流行病学特征、病因因素、临床病理学和分子特征、预后以及治疗方式的最新研究进展。版权所有 © 2024 中华医学会，由 Wolters Kluwer, Inc. 制作，CC- BY-NC-ND 许可证。

The incidence of early-onset gastric cancer (EOGC) is consistently increasing, and its etiology is notably complex. This increase may be attributed to distinctive factors that differ from those associated with late-onset gastric cancer (LOGC), including genetic predispositions, dietary factors, gastric microbiota dysbiosis, and screening of high-risk cases. These factors collectively contribute to the onset of cancer. EOGC significantly differs from LOGC in terms of clinicopathological and molecular characteristics. Moreover, multiple differences in prognosis and clinical management also exist. This study aimed to systematically review the latest research advancements in the epidemiological characteristics, etiological factors, clinicopathological and molecular features, prognosis, and treatment modalities of EOGC.Copyright © 2024 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license.