不育商业公力的睾丸肿瘤：一项总体，组织学和免疫组织化学研究
Testicular tumors in commercial boars with infertility: A gross, histologic, and immunohistochemical study
影响因子:1.70000
分区:农林科学2区 / 兽医学2区 病理学3区
发表日期:2025 Jan
作者:
Raquel Ausejo, María Victoria Falceto, Olga Mitjana, Ana María Garrido, Juan José Badiola, Bernardino Moreno
摘要
公猪中的肿瘤并不常见，睾丸肿瘤甚至更罕见。这项研究描述了具有生育能力问题的商业公猪中一系列睾丸肿瘤的病理和免疫组织化学特征。在333只动物中有19例（19/333，5.9％）中检测到肿瘤。从宏观上看，在13只（13/19，68％）的公猪中观察到肿瘤，而仅通过微观检查检测到6例（6/19，32％）。在1只野猪中观察到睾丸增大，而在其他公猪中，仅在去除阴囊皮肤或睾丸切片后才观察到肿瘤。从组织学上讲，肿瘤被分类为seminomas（16/19，84％），混合生殖细胞 - 细胞肿瘤（2/19，11％）和B细胞淋巴瘤（1/19，5％）。 Seminomas具有3种不同的生长模式：内部（6/16，38％），漫射（4/16，25％）和腹部/弥漫性（6/16，38％）。所有在宏观检查中不明显的肿瘤均为细胞内囊肿。在2例中观察到肠内转移，在1例中观察到位于pampinorplesplexus中的内植物转移。在1个精子瘤中，还涉及rete睾丸。通过免疫组织化学，所有囊内囊肿均为C-KIT，细胞角蛋白和波形蛋白为阴性。在弥漫性精瘤中，C-KIT和细胞角蛋白也为阴性，而在某些地区，波形蛋白显示出颗粒状或核周细胞质标记。 PAX-5和CD-3抗体将淋巴瘤分类为B细胞淋巴瘤。这项研究表明，公猪中的睾丸肿瘤可能比以前报道的更为普遍，尤其是在进行微观检查时。它还表明，猪中的睾丸肿瘤主要是seminomas。
Abstract
Tumors in boars are uncommon, and testicular tumors even rarer. This study describes the pathological and immunohistochemical characteristics of a case series of testicular tumors in commercial boars with fertility problems. Tumors were detected in 19 of 333 animals (19/333, 5.9%). Macroscopically, tumors were observed in 13 (13/19, 68%) boars, while 6 cases (6/19, 32%) were only detected by microscopic examination. Testicular enlargement was observed in 1 boar, while in the others, tumors were only observed after removal of the scrotal skin or after sectioning of the testis. Histologically, tumors were classified as seminomas (16/19, 84%), mixed germ cell-stromal tumors (2/19, 11%), and B-cell lymphoma (1/19, 5%). Seminomas had 3 different growth patterns: intratubular (6/16, 38%), diffuse (4/16, 25%), and intratubular/diffuse (6/16, 38%). All tumors that were not evident on macroscopic examination were intratubular seminomas. Intratesticular metastases were observed in 2 cases and extratesticular metastases, located in the pampiniform plexus, were observed in 1 case. In 1 seminoma, the rete testis was also involved. By immunohistochemistry, all intratubular seminomas were negative for c-kit, cytokeratin, and vimentin. In diffuse seminomas, c-kit and cytokeratin were also negative, while vimentin showed granular or perinuclear cytoplasmic labeling in some areas. PAX-5 and CD-3 antibodies classified the lymphoma as a B-cell lymphoma. This study suggests that testicular tumors in boars may be more common than previously reported, especially when microscopic examination is performed. It also shows that testicular tumors in pigs are predominantly seminomas.