超重和肥胖正在全球范围内加剧公共健康问题，印度的超重和肥胖人口也正在大幅增加。 肿瘤坏死因子 α (TNF-α) 是一种细胞因子，在与肥胖相关的代谢紊乱方面尤其受到关注。 本研究旨在评估超重和肥胖成年人的 TNF-α 水平，并探讨其与印度东北部人群代谢综合征和相关生化参数的相关性。进行了一项比较研究，将 200 名参与者分为四组：50 名健康对照，50 名超重个人，50 名无代谢综合征的肥胖者和 50 名患有代谢综合征的肥胖者。使用酶联免疫吸附测定（ELISA）方法测量血清TNF-α水平。使用标准方法进行人体测量和生化分析，包括葡萄糖和血脂谱。TNF-α水平在超重个体（128.5±35.7 pg/ml）、无代谢综合征的肥胖个体（171.5±13.6 pg/ml）中显着升高，以及患有代谢综合征的肥胖个体（238.6±62 pg/ml）与正常受试者（对照；21.7±11.8 pg/ml）相比。 TNF-α与体重指数（BMI）、腰臀比（WHR）、颈围、血糖、胆固醇、甘油三酯呈正相关，与高密度脂蛋白胆固醇（HDL-C）呈负相关超重和肥胖个体中 TNF-α 水平升高表明其在脂肪组织内的代谢紊乱和免疫激活中发挥作用。这些发现强调了监测 TNF-α 作为代谢综合征风险潜在生物标志物的重要性，并强调需要对印度东北部人群进行有针对性的干预措施，以减轻肥胖和相关代谢紊乱对健康的影响。版权所有 © 2024，Eswar 等人。

Overweight and obesity are escalating public health concerns globally, and India is also experiencing a significant rise in the population of overweight and obese people. Tumour necrosis factor alpha (TNF-α) is a type of cytokine that has garnered attention in particularly obesity-related metabolic disturbances. This study aimed to assess TNF-α levels in overweight and obese adults and explore its correlation with metabolic syndrome and associated biochemical parameters in the northeastern Indian population.A comparative study was conducted involving 200 participants divided into four groups: 50 healthy controls, 50 overweight individuals, 50 obese individuals without metabolic syndrome and 50 obese individuals with metabolic syndrome. Serum TNF-α levels were measured using the enzyme-linked immunosorbent assay (ELISA) method. Anthropometric measurements and biochemical analyses, including glucose and lipid profiles, were performed using standard methods.TNF-α levels were significantly elevated in overweight individuals (128.5±35.7 pg/ml), obese individuals without metabolic syndrome (171.5±13.6 pg/ml), and obese individuals with metabolic syndrome (238.6±62 pg/ml) compared to normal subjects (controls; 21.7±11.8 pg/ml). Positive correlations were observed between TNF-α and body mass index (BMI), waist-to-hip ratio (WHR), neck circumference, glucose, cholesterol, triglycerides, and negative correlation was found high-density lipoprotein cholesterol (HDL-C).Elevated TNF-α levels in overweight and obese individuals suggest its role in metabolic disturbances and immune activation within the adipose tissue. These findings underscore the importance of monitoring TNF-α as a potential biomarker for metabolic syndrome risk, highlighting the need for targeted interventions in the northeastern Indian population to mitigate the health impacts of obesity and associated metabolic disorders.Copyright © 2024, Eswar et al.