初次摘除后视网膜母细胞瘤的高风险组织病理学特征：对来自 5 大洲 1426 名患者的全球研究。
High-Risk Histopathological Features of Retinoblastoma following Primary Enucleation: A Global Study of 1426 Patients from 5 Continents.
发表日期：2024 Aug 14
作者：
Swathi Kaliki, Vijitha S Vempuluru, Komal Rajendra Bakal, Samten Dorji, Vishakha Tanna, Charlotte N Shields, Samuel J Fallon, Vishal Raval, Alia Ahmad, Asma Mushtaq, Mahvish Hussain, Yacoub A Yousef, Mona Mohammad, Soma Rani Roy, Fahmida Huque, Ushakova Tatiana, Serov Yuri, Polyakov Vladimir, Sandro Casavilca Zambrano, Sandra Alarcón-León, Cinthya Valdiviezo-Zapata, Maria Vargas-Martorellet, Cynthia Gutierrez-Chira, Mario Buitrago, Joana Sánchez Ortiz, Rosdali Diaz-Coronado, Devjyoti Tripathy, Suryasnata Rath, Gaurav Patil, Jesse L Berry, Sarah Pike, Brianne Brown, Mika Tanabe, Shahar Frenkel, Maya Eiger-Moscovich, Jacob Pe'er, Carol L Shields, Ralph C Eagle, Andrea Laiton, Ana Maria Velasco, Katherine Vega, Joseph DeSimone, Kavya Madhuri Bejjanki, Anasua Ganguly Kapoor, Anusha Venkataraman, Victoria Bryant, M Ashwin Reddy, Mandeep S Sagoo, G Baker Hubbard, Corrina P Azarcon, Thomas A Olson, Hans Grossniklaus, Olivia Rolfe, Sandra E Staffieri, Roderick O'Day, Anu A Mathew, James E Elder, John D McKenzie, Ido Didi Fabian, Rachel Shemesh, Vicktoria Vishnevskia-Dai, Mohammed Hasnat Ali, Saumya Jakati, Dilip K Mishra, Vijay Anand Reddy Palkonda
来源：
MEDICINE & SCIENCE IN SPORTS & EXERCISE
摘要：
评估视网膜母细胞瘤 (RB) 眼睛初次摘除后的高风险组织病理学特征 (HRHF) 并评估各大洲患者的预后。对来自五大洲的 1426 只初次摘除 RB 眼进行回顾性研究。其中 923 只 (65%) 来自亚洲 (AS)、澳大利亚 (AUS) 27 名 (2%)、欧洲 (EUR) 120 名 (8%)、北美 (NA) 162 名 (11%) 和南美洲 (SA) 194 名 (14%) ）。根据大陆（AS vs. AUS vs. EUR vs. NA vs. SA），组织病理学特征包括大规模脉络膜浸润（31% vs. 7% vs. 13% vs. 19% vs. 27%，p=0.001 ）、层后视神经浸润（27% vs. 0% vs. 16% vs. 21% vs. 19%，p=0.0006）、巩膜浸润（5% vs. 0% vs. 4% vs. 2%） vs. 7%，p=0.13），以及显微镜下巩膜外浸润（4% vs. 0% vs. <1% vs. <1% vs. 4%，p=0.68）。 761 名 (53%) 患者接受了辅助化疗联合/不联合眼眶放疗。根据不同大陆的 Kaplan-Meier 估计（AS vs. AUS vs. EUR vs. NA vs. SA），眼眶肿瘤复发的 6 年风险分别为 5% vs. 2% vs. 0% vs. 0% vs 12% (p<0.001)，全身转移的比例为 8% vs. 5% vs. 2% vs. 0% vs. 13% (p=0.001)，死亡比例为 10% vs. 3% vs. 2 % vs. 0% vs. 11% (p<0.001) 患者。各大洲 RB 的浸润组织病理学特征存在很大差异，导致不同的结果。与 AUS、EUR 和 NA 相比，SA 和 AS 的眼眶肿瘤复发、全身转移和死亡风险更高。版权所有 © 2024 作者。由 Wolters Kluwer Health, Inc. 代表 Opthalmic Communications Society, Inc. 出版。
To evaluate high-risk histopathological features (HRHF) following primary enucleation of eyes with retinoblastoma (RB) and assess the patient outcomes across continents.Retrospective study of 1426 primarily enucleated RB eyes from five continents.Of all, 923 (65%) were from Asia (AS), 27 (2%) from Australia (AUS), 120 (8%) from Europe (EUR), 162 (11%) from North America (NA), and 194 (14%) from South America (SA). Based on the continent (AS vs. AUS vs. EUR vs. NA vs. SA), the histopathology features included massive choroidal invasion (31% vs. 7% vs. 13% vs. 19% vs. 27%, p=0.001), post-laminar optic nerve invasion (27% vs. 0% vs. 16% vs. 21% vs. 19%, p=0.0006), scleral infiltration (5% vs. 0% vs. 4% vs. 2% vs. 7%, p=0.13), and microscopic extrascleral infiltration (4% vs. 0% vs. <1% vs. <1% vs. 4%, p=0.68). Adjuvant chemotherapy with/without orbital radiotherapy was given in 761 (53%) patients. Based on Kaplan-Meier estimates in different continents (AS vs. AUS vs. EUR vs. NA vs. SA), the 6-year risk of orbital tumor recurrence was 5% vs. 2% vs. 0% vs. 0% vs. 12% (p<0.001), systemic metastasis was reported in 8% vs. 5% vs. 2% vs. 0% vs. 13% (p=0.001), and death in 10% vs. 3% vs. 2% vs. 0% vs. 11% (p<0.001) patients.There is a wide variation in the infiltrative histopathology features of RB across continents, resulting in variable outcomes. SA and AS had a higher risk of orbital tumor recurrence, systemic metastasis, and death compared to AUS, EUR, and NA.Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the Opthalmic Communications Society, Inc.