治理基础设施简化了人类多能干细胞 (SC) 系的科学和伦理来源验证。然而，科学发展（例如 SC 衍生胚胎模型、类器官）对存储生物样本的研究治理方法提出了挑战，质疑知情同意 (IC) 模型的有效性。同样，电子医疗平台正在推动数据处理的重大变革，促使人们重新评估 IC。鉴于这些发展，参与式研究平台被认为是促进纵向参与、互动决策和动态治理的有效工具。本视角借鉴了欧洲在生物样本库和 SC 研究中试点动态 IC 的举措，探讨了为 SC 实施动态 IC 和治理的好处和挑战。版权所有 © 2024 作者。由爱思唯尔公司出版。保留所有权利。

Governance infrastructures streamline scientific and ethical provenance verification of human pluripotent stem cell (SC) lines. Yet, scientific developments (e.g., SC-derived embryo models, organoids) challenge research governance approaches to stored biospecimens, questioning the validity of informed consent (IC) models. Likewise, e-health platforms are driving major transformations in data processing, prompting a reappraisal of IC. Given these developments, participatory research platforms are identified as effective tools to promote longitudinal engagement, interactive decision-making, and dynamic governance. Learning from European initiatives piloting dynamic IC for biobanking and SC research, this Perspective explores the benefits and challenges of implementing dynamic IC and governance for SC.Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.