灾难性血栓形成是一种以高凝倾向为特征的严重疾病，通常在短时间内导致不同血管中发生多种血栓栓塞事件。多种疾病与灾难性血栓形成有关，包括灾难性抗磷脂综合征、血栓性抗血小板因子 4 免疫紊乱、血栓性微血管病、癌症、嗜酸性粒细胞增多综合征、妊娠、感染、创伤和药物。血栓风暴是一种医疗紧急情况，其管理对医生来说是一个严峻的挑战。除了及时开始抗凝治疗外，患者的预后还取决于对潜在病症的早期识别和可能的治疗。在这篇叙述性综述中，我们总结了灾难性血栓形成的主要特征，分析了引发这种危及生命的并发症的各种情况。最后，提出了一种对灾难性血栓形成患者进行诊断检查和初始管理的算法。Thieme。版权所有。

Catastrophic thrombosis is a severe condition characterized by a hypercoagulable tendency, leading to multiple thromboembolic events in different blood vessels, usually within a short timeframe. Several conditions have been associated with the development of catastrophic thrombosis, including the catastrophic antiphospholipid syndrome, thrombotic anti-platelet factor 4 immune disorders, thrombotic microangiopathies, cancers, the hyper-eosinophilic syndrome, pregnancy, infections, trauma, and drugs. Thrombotic storm represents a medical emergency whose management represents a serious challenge for physicians. Besides the prompt start of anticoagulation, a patient's prognosis depends on early recognition and possible treatment of the underlying condition. In this narrative review, we summarize the main characteristics of catastrophic thrombosis, analyzing the various conditions triggering such life-threatening complication. Finally, an algorithm with the diagnostic workup and the initial management of patients with catastrophic thrombosis is presented.Thieme. All rights reserved.