研究动态
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消融适合小肾脏肿块 (SRM) 吗?荟萃分析。

Is Ablation Suitable For Small Renal Masses (SRMs)? A Meta-Analysis.

发表日期:2024 Aug 15
作者: Si Ge, Zuoping Wang, Yunxiang Li, Lei Zheng, Lijian Gan, Zhiqiang Zeng, Chunyang Meng, Kangsen Li, Jiakai Ma, Deyu Wang, Yuan Ren
来源: ACADEMIC RADIOLOGY

摘要:

比较肾小肿块(SRM)消融和肾部分切除术的围手术期和肿瘤学结果。我们严格按照 PRISMA 标准进行荟萃分析,质量评估遵循 AMSTAR 标准。系统地检索了四个数据库:Embase、PubMed、Cochrane Library 和 Web of Science。检索时间范围为建库至2023年11月。采用Stata16统计软件进行统计分析。加权平均差(WMD)代表连续性变量,比值比或相对风险(OR/RR)代表二分变量,计算95%置信区间(95%CI)。 共有27项研究,包括6030名患者。结果显示,接受肾部分切除术的患者年龄较小(WMD = -5.45 岁,95%CI [-7.44, -3.46],P < 0.05),手术时间较长(WMD = 64.91 分钟,95%CI [44.47, 85.34] ,P < 0.05),住院时间较长(WMD = 2.91 天,95% CI [2.04, 3.78],P < 0.05),估计失血量较多(WMD = 97.76 ml,95% CI [69.48, 126.04) ]。总体并发症发生率较高(OR = 1.84,95%CI [1.48,2.29],P <0.05),主要并发症发生率较高(OR = 1.98,95%CI [1.36,2.88]。 ],P < 0.05),且复发率较低(OR = 0.32,95%Cl [0.20,0.50],P < 0.05)。然而,消融和肾部分切除术在癌症特异性生存 (CSS)(HR = 2.07,95%CI [0.61,7.04],P > 0.05)、总生存 (OS)(HR = 1.24,95%)方面没有差异。 CI [0.58, 2.65], P > 0.05) 和无复发生存率 (RFS) (HR = 2.68, 95% CI [0.91, 7.88], P > 0.05)。 接受肾部分切除术的患者年龄较小,手术时间较长且住院时间长,并发症发生率较高。然而,肾部分切除术和消融术之间的 CSS、OS 和 RFS 没有显着差异,但需要更多精心设计、高质量的研究来证实这一点。版权所有 © 2024 大学放射科医生协会。由爱思唯尔公司出版。保留所有权利。
To compare perioperative and oncology outcomes of ablation and partial nephrectomy in small renal masses (SRMs).We conduct this meta-analysis strictly according to the PRISMA standard, and the quality evaluation follows the AMSTAR standard. Four databases, Embase, PubMed, Cochrane Library, and Web of Science, were systematically searched. The search time range is from database creation to November 2023. Stata16 statistical software was used for statistical analysis. Weighted mean difference (WMD) represented continuity variables, odds ratio or relative risk (OR/RR) represented dichotomies variables, and 95% confidence intervals (95%CI) were calculated.A total of 27 studies, including 6030 patients. Results showed that patients undergoing partial nephrectomy were younger (WMD = -5.45 years, 95%CI [-7.44, -3.46], P < 0.05), had longer operation time (WMD = 64.91 min, 95%CI [44.47, 85.34], P < 0.05), had longer length of stay (WMD = 2.91 days, 95%CI [2.04, 3.78], P < 0.05), and had more estimated blood loss (WMD = 97.76 ml, 95%CI [69.48, 126.04]. P < 0.05), the overall complication rate was higher (OR = 1.84, 95%CI [1.48, 2.29], P < 0.05), the major complication rate was higher (OR = 1.98, 95%CI [1.36, 2.88], P < 0.05), and the recurrence rate was lower (OR = 0.32, 95%Cl [0.20, 0.50], P < 0.05). However, there were no differences between ablation and partial nephrectomy in cancer-specific survival (CSS) (HR = 2.07, 95%CI [0.61, 7.04], P > 0.05), overall survival (OS) (HR = 1.24, 95%CI [0.58, 2.65], P > 0.05), and recurrence-free survival (RFS) (HR = 2.68, 95%CI [0.91, 7.88], P > 0.05).Patients undergoing partial nephrectomy are younger, have longer operation time and length of stay, and have higher complication rate. However, there was no significant difference in CSS, OS, and RFS between partial nephrectomy and ablation, but more well-designed, high-quality studies are needed to confirm this.Copyright © 2024 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved.