本研究的目的是记录选定的 cT3M0 喉鳞状细胞癌 (SCC) 患者环上部分喉切除术 (SCPL) 后 10 年的结果。这项现实生活中的回顾性观察研究分析了 168 名孤立的、未经治疗的患者的初始队列。选择了 cT3M0 喉 SCC，这些病例在 1973 年至 2013 年期间由 SCPL 连续管理，并在法国一家学术和三级转诊护理中心对 92% 的病例进行随访直至死亡或至少 10 年。分别对 148、77、136 和 27 例患者进行了前期诱导化疗、杓状软骨切除、II-IV 级颈清扫术和术后放射治疗。主要目标是确定 10 年精算局部控制和喉部保存估计。次要目标包括 10 年精算生存率和死因分析，以及终点与临床变量之间相关性的评估。显着性阈值设定为 p<0.005。十年精算局部控制、喉保留和生存率估计分别为 90%、85% 和 52%。抢救治疗的总体局部控制率为 99%。异时性第二原发癌、无鳞状细胞癌证据的并发疾病、SCPL相关死亡和不受控制的局部复发分别占死亡原因的31%、26%、7%和2%。在单变量分析中，当切除边缘为 R0 和 R1 时，总体局部复发率和喉保留率差异显着，分别从 5% 至 54% 和 90% 至 46%。本研究强调了 SCPL 后 10 年的成功结果，进一步提供了支持将其纳入喉内 cT3 SCC 保守装备的证据。4 喉镜，2024 年。© 2024 作者。 《喉镜》由 Wiley periodicals LLC 代表美国喉科、鼻科和耳科协会出版。

The aim of this study was to document 10-year outcomes after supracricoid partial laryngectomy (SCPL) in selected cT3M0 laryngeal squamous cell carcinoma (SCC) patients.This real-life retrospective observational study analyzed an inception cohort of 168 patients with isolated, untreated, selected cT3M0 laryngeal SCC, that were consecutively managed by SCPL during the period 1973-2013, and followed up until death or for a minimum of 10 years in 92% of cases at a single French academic and tertiary referral care center. Prior induction chemotherapy, arytenoid cartilage removal, level II-IV neck dissection, and postoperative radiation therapy were performed on 148, 77, 136, and 27 patients, respectively. The main objective was to determine 10-year actuarial local control and laryngeal preservation estimates. Secondary objectives included 10-year actuarial survival and cause-of-death analysis, and assessment of correlations between endpoints and clinical variables. The significance threshold was set at p < 0.005.Ten-year actuarial local control, laryngeal preservation, and survival estimates were 90%, 85%, and 52%, respectively. Salvage treatment resulted in an overall 99% local control rate. Metachronous second primary cancer, intercurrent disease without evidence of SCC, SCPL-related death, and uncontrolled local recurrence accounted for 31%, 26%, 7%, and 2% of causes of death. On univariate analysis, overall local recurrence and laryngeal preservation rates varied significantly, from 5% to 54% and 90% to 46% when resection margins were R0 and R1, respectively.The present study highlighted successful 10-year outcomes after SCPL, providing further evidence in favor of its integration into the conservative armamentarium for endolaryngeal cT3 SCC.4 Laryngoscope, 2024.© 2024 The Author(s). The Laryngoscope published by Wiley Periodicals LLC on behalf of The American Laryngological, Rhinological and Otological Society, Inc.