胶质母细胞瘤是最具侵袭性的脑癌，患者生存预后不佳。胶质瘤干细胞是癌细胞的一个亚群，可驱动肿瘤的发生、自我更新和对治疗的抵抗，并与微环境一起在胶质母细胞瘤的维持和进展中发挥至关重要的作用。去甲肾上腺素、多巴胺和血清素等神经递质对胶质母细胞瘤的发展具有相反的作用，根据细胞环境并通过它们对胶质瘤干细胞的作用刺激或抑制其进展，可能会改变表观遗传景观。最近的研究表明，血清素和多巴胺会诱导哺乳动物大脑（甚至可能是胶质母细胞瘤）中与转录可塑性相关的染色质修饰。然而，由于其对胶质母细胞瘤治疗的潜在影响，这个话题仍然需要探索。此外，必须考虑神经递质的作用取决于肿瘤的微环境，因为它可以显着影响癌细胞的反应和行为。本综述探讨了神经递质作为胶质母细胞瘤发展调节剂的可能作用，重点关注它们对胶质瘤干细胞染色质的影响。© 2024。作者。

Glioblastoma is the most aggressive brain cancer with an unfavorable prognosis for patient survival. Glioma stem cells, a subpopulation of cancer cells, drive tumor initiation, self-renewal, and resistance to therapy and, together with the microenvironment, play a crucial role in glioblastoma maintenance and progression. Neurotransmitters such as noradrenaline, dopamine, and serotonin have contrasting effects on glioblastoma development, stimulating or inhibiting its progression depending on the cellular context and through their action on glioma stem cells, perhaps changing the epigenetic landscape. Recent studies have revealed that serotonin and dopamine induce chromatin modifications related to transcriptional plasticity in the mammalian brain and possibly in glioblastoma; however, this topic still needs to be explored because of its potential implications for glioblastoma treatment. Also, it is essential to consider that neurotransmitters' effects depend on the tumor's microenvironment since it can significantly influence the response and behavior of cancer cells. This review examines the possible role of neurotransmitters as regulators of glioblastoma development, focusing on their impact on the chromatin of glioma stem cells.© 2024. The Author(s).