繁殖对于动物来说至关重要。为了使其成功，社会行为、生理学和配子产生的协调是必要的。如何感知社会线索以及它们如何影响生理和配子发生？虽然从昆虫到哺乳动物的雌性已经提供了关于这种协调的多种见解，但它在雄性中的存在仍然很大程度上未知。在这里，通过使用雄性果蝇作为模型，我们描述了一种现象，即潜在交配伙伴的可用性会触发睾丸干细胞群的激活状态，从而促进精子发生。我们揭示了它对信息素交流的依赖，即使在没有与雌性交配或其他互动的情况下也是如此。最后，我们确定了负责肌肉分泌的肿瘤坏死因子 α (TNF-α)/Eiger 和神经元分泌的章鱼胺触发器的器官间通讯信号网络，分别是 Jun N 末端激酶 (JNK) 途径和钙动力学的变化。囊肿干细胞。因此，生殖系干细胞会增加增殖。版权所有 © 2024 作者。由爱思唯尔公司出版。保留所有权利。

Reproduction is paramount to animals. For it to be successful, a coordination of social behavior, physiology, and gamete production is necessary. How are social cues perceived and how do they affect physiology and gametogenesis? While females, ranging from insects to mammals, have provided multiple insights about this coordination, its existence remains largely unknown in males. Here, by using the Drosophila male as a model, we describe a phenomenon by which the availability of potential mating partners triggers an activation state on the stem cell populations of the testis, boosting spermatogenesis. We reveal its reliance on pheromonal communication, even in the absence of mating or other interactions with females. Finally, we identify the interorgan communication signaling network responsible-muscle-secreted tumor necrosis factor alpha (TNF-α)/Eiger and neuronally secreted octopamine trigger, respectively, the Jun N-terminal kinase (JNK) pathway and a change in calcium dynamics in the cyst stem cells. As a consequence, germ line stem cells increase their proliferation.Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.