如今，药物已被证明具有严重的副作用，而植物植物的生物活性成分被证明可有效治疗多种以氧化应激增强和轻度炎症为特征的疾病，这些疾病通常与最小的不良事件相关。香豆酰酪胺有多种命名法，如狗帕嗪、N-对反式香豆酰胺、对香豆酰胺和 N-对香豆酰胺，由于其强大的抗炎和抗氧化作用，可能成为解决健康问题的有前途的生物活性成分。这篇综述首次对香豆酰酪胺进行了深入分析，香豆酰酪胺是一种在多种植物中发现的有趣的苯丙素物质。事实上，我们已经对香豆酰酪胺的生物学特性、化学属性和合成过程进行了深入研究。本次分析回顾并考虑了所有先前与香豆酰酪胺的生物和药理活性特性的发现、提取、生物合成和表征相关的研究。截至 2024 年 2 月 12 日，在同行评审的英语期刊上发表的所有文章都经过了相应数据库的初步编译期间的检查。多种植物化学物质显示，香豆酰酪胺是羟基肉桂酸的中性酰胺，往往作为一种物质集中在植物中。对抗病原体引起的感染的反应，是从几种草药中提取的，如大麻、茄子、葱、番荔枝、黄精和番茄。由于香豆酰胺能有效抑制 α-葡萄糖苷酶的作用，因此已显示出抗高血糖活性，并可能对糖尿病和代谢紊乱产生影响。它具有相当大的抗炎和抗氧化作用。这些结果是通过体内和体外的生物和药理学研究获得的。此外，香豆酰酪胺已被证明具有降低胆固醇和神经保护的功效，从而减少心脏和血管疾病的发病率，并有助于预防神经系统疾病。香豆酰胺的其他有趣特性包括抗癌、抗菌、抗脲酶、抗真菌、抗病毒和抗痛经活性。靶向途径涵盖不同分子水平的活性，特别是通过诱导内质网应激依赖性细胞凋亡、细胞周期停滞以及抑制癌细胞的生长、存活和增殖。尽管计算机、体内和体外实验的结果说明了香豆酰酪胺的特性和作用方式，但仍需要进一步研究以充分开发其治疗潜力。为了提高我们对化合物的药效作用和药代动力学途径的了解，首先应该进行大规模研究。为了确定香豆酰酪胺在临床上是否安全有效，还需要在临床和毒理学领域进行进一步的研究。这项即将进行的研究对于实现这种物质作为天然药物的整体效力以及与其他药物的潜在协同作用至关重要。版权所有 © 2024。由 Elsevier B.V. 出版。

Today, pharmaceutical drugs have been shown to have serious side effects, while the bioactive components of botanical plants are proven to be effective in the treatment of several diseases marked by enhanced oxidative stress and mild inflammation, often associated with minimal adverse events. Coumaroyltyramine, designated by various nomenclatures such as paprazine, N-p-trans-coumaroyltyramine, p-coumaroyltyramine and N-p-coumaroyltyramine, could be a promising bioactive ingredient to address health issues thanks to its powerful anti-inflammatory and antioxidant effects. This review represents the first in-depth analysis of coumaroyltyramine, an intriguing phenylpropanoid substance found in many species of plants. In fact, an in-depth examination of coumaroyltyramine's biological characteristics, chemical attributes, and synthesis process has been undertaken. All previous research relating to the discovery, extraction, biosynthesis, and characterization of the biologically and pharmacologically active properties of coumaroyltyramine has been reviewed and taken into consideration in this analysis. All articles published in a peer-reviewed English-language journal were examined between the initial compilations of the appropriate database until February 12, 2024. A variety of phytochemicals revealed that coumaroyltyramine is a neutral amide of hydroxycinnamic acid that tends to concentrate in plants as a reaction against infection caused by pathogens and is extracted from several medicinal herbs such as Cannabis sativa, Solanum melongena, Allium bakeri, Annona cherimola, Polygonatum zanlanscianense, and Lycopersicon esculentum. Thanks to its effectiveness in suppressing the effect of the enzyme α-glucosidase, coumaroltyramine has demonstrated antihyperglycemic activity and could have an impact on diabetes and metabolic disorders. It has considerable anti-inflammatory and antioxidant effects. These results were obtained through biological and pharmacological studies in silico, in vivo, and in vitro. In addition, coumaroyltyramine has demonstrated hypocholesterolemic and neuroprotective benefits, thereby diminishing heart and vascular disease incidence and helping to prevent neurological disorders. Other interesting properties of coumaroltyramine include anticancer, antibacterial, anti-urease, antifungal, antiviral, and antidysmenorrheal activities. Targeted pathways encompass activity at different molecular levels, notably through induction of endoplasmic reticulum stress-dependent apoptosis, arrest of the cell cycle, and inhibition of the growth of cancer cells, survival, and proliferation. Although the findings from in silico, in vivo, and in vitro experiments illustrate coumaroyltyramine's properties and modes of action, further research is needed to fully exploit its therapeutic potential. To improve our understanding of the compound's pharmacodynamic effects and pharmacokinetic routes, large-scale research should first be undertaken. To determine whether coumaroyltyramine is clinically safe and effective, further studies are required in the clinical and toxicological fields. This upcoming research will be crucial to achieving the overall potency of this substance as a natural drug and in terms of its potential synergies with other drugs.Copyright © 2024. Published by Elsevier B.V.