代谢功能障碍相关脂肪肝病（MAFLD）的全球发病率一直在稳步上升，使其成为一种主要的慢性肝病。 MAFLD 是指与 2 型糖尿病、肥胖相关的代谢综合征。然而，其病理生理学复杂，目前尚无有效且批准的治疗药物。芦丁是一种天然存在的多酚类黄酮，广泛分布于水果、蔬菜和其他植物中。它具有多种生物活性特性，如抗氧化、抗癌、抗炎和神经保护活性，使其成为一种极具前景的植物化学物质。芦丁在治疗多种代谢性疾病方面显示出巨大潜力，近年来受到广泛关注。幸运的是，各种研究已经验证了芦丁在治疗代谢紊乱方面的广泛生物学功能。尽管芦丁对MAFLD具有保肝作用的确切病理生理机制尚未完全阐明。这篇综述全面概述了芦丁对 MAFLD 的多方面预防和治疗作用，包括调节脂质代谢、减少胰岛素抵抗、减少炎症和氧化应激、对抗肥胖以及对肠道菌群的影响。本文详细介绍了芦丁在 MAFLD 发病机制中的已知分子靶点和途径。致力于为MAFLD的治疗提供新思路，加速其从临床到临床的转化。版权所有©2024。Elsevier B.V.出版。

The global incidence of metabolic dysfunction-associated fatty liver disease (MAFLD) has been steadily increasing, making it a leading chronic liver disease. MAFLD refers to a metabolic syndrome linked with type 2 diabetes mellitus, obesity. However, its pathophysiology is complex, there are currently no effective and approved medicines for therapy. Rutin, a naturally occurring polyphenolic flavonoid, is widely distributed in fruits, vegetables, and other plants. It exhibits a plethora of bioactive properties, such as antioxidant, anticancer, and anti-inflammatory and neuroprotective activities, making it an extremely promising phytochemical. Rutin has shown great potential in the treatment of a wide variety of metabolic diseases and received considerable attention in recent years. Fortuitously, various research studies have validated rutin's extensive biological functions in treating metabolic disorders. Despite the fact that the exact pathophysiological mechanisms through which rutin has a hepatoprotective effect on MAFLD are still not fully elucidated. This review comprehensively outlines rutin's multifaceted preventive and therapeutic effects in MAFLD, including the modulation of lipid metabolism, reduction of insulin resistance, diminution of inflammation and oxidative stress, combatting of obesity, and influence on intestinal flora. This paper details the known molecular targets and pathways of rutin in MAFLD pathogenesis. It endeavored to provide new ideas for treating MAFLD and accelerating its translation from bench to bedside.Copyright © 2024. Published by Elsevier B.V.