光热疗法（PTT）是一种有前景的乳腺癌治疗方法。然而，PTT引起的过度炎症反应可能会加剧肿瘤转移。同时，癌细胞过度表达的热休克蛋白（HSP）可以保护它们在PTT过程中免受高温影响。因此，为了减轻PTT诱导的炎症并抑制肿瘤转移，开发了一种共同负载小檗碱（BBR）和吲哚菁绿（ICG）的叶酸受体靶向热敏脂质体（BI-FA-LP）。 BI-FA-LP利用增强渗透性和滞留（EPR）效应和FA受体介导的内吞作用选择性地在肿瘤处积累，减少治疗过程中的脱靶毒性。靶向肿瘤部位后，激光照射下BI-FA-LP释放BBR和ICG，ICG表现出良好的光热性能，而BBR在PTT过程中抑制HSP70和HSP90的表达，发挥化学光热协同抗肿瘤作用。此外，BBR可以抑制PTT诱导的炎症，从而抑制肿瘤转移并改善组织损伤。因此，这种多功能脂质体为乳腺癌治疗提供了增强 PTT 和抗炎作用的新策略。版权所有 © 2024。由 Elsevier B.V. 出版。

Photothermal therapy (PTT) is a prospective therapeutic method for breast cancer. However, excess inflammatory response induced by PTT may aggravate tumor metastasis. Meanwhile, the overexpressed heat shock proteins (HSPs) by cancer cells can protect them from hyperthermia during PTT. Therefore, to attenuate the PTT-induced inflammation and inhibit tumor metastasis, a folate receptor-targeted thermo-sensitive liposome (BI-FA-LP) co-loading Berberine (BBR) and Indocyanine green (ICG) was developed. BI-FA-LP utilized enhanced permeability and retention (EPR) effect and FA receptor-mediated endocytosis to selectively accumulate at tumor, reducing off-target toxicity during the treatment. After targeting to the tumor site, BBR and ICG were released from BI-FA-LP upon laser irradiation, and ICG showed good photothermal performance, while BBR inhibited HSP70 and HSP90 expression during PTT, exerting chemo-photothermal synergetic anti-tumor effect. Moreover, BBR could suppress the PTT induced inflammation, thus inhibiting tumor metastasis and ameliorating tissue injury. Thus, this versatile liposome provided a new strategy to enhance PTT and anti-inflammatory effects for breast cancer treatment.Copyright © 2024. Published by Elsevier B.V.