免疫调节疗法是改善免疫系统功能的有益策略。如今，由于免疫紊乱、癌症和新病毒性疾病的日益流行，更需要引入更有效、更少副作用的免疫调节化合物。微生物衍生物是发现许多具有各种医学特性的新型化合物的肥沃且有吸引力的基础。许多源自细菌的天然化合物的发现，例如具有前景的免疫调节活性的次级代谢物，代表了该主题在药物发现中的重要性，并强调了该领域研究的连贯来源的必要性。考虑到这一需求，在本次综述中，我们的目标是关注有关细菌次级代谢产物和微生物衍生的天然免疫调节剂的免疫调节作用的最新信息。版权所有 © 2024。由 Elsevier B.V. 出版。

Immunomodulatory therapies are beneficial strategies for the improvement of immune system function. Today, due to the increasing prevalence of immune disorders, cancer, and new viral diseases, there is a greater need to introduce immunomodulatory compounds with more efficiency and fewer side effects. Microbial derivatives are fertile and attractive grounds for discovering lots of novel compounds with various medical properties. The discovery of many natural compounds derived from bacterial sources, such as secondary metabolites with promising immunomodulating activities, represents the importance of this topic in drug discovery and emphasizes the necessity for a coherent source of study in this area. Considering this need, in this review, we aim to focus on the current information about the immunomodulatory effects of bacterial secondary metabolites and natural immunomodulators derived from microorganisms.Copyright © 2024. Published by Elsevier B.V.