多成分传统药物处方在埃塞俄比亚广泛用于疾病治疗。然而，不同从业者、文化和地点之间的不一致阻碍了可靠治疗药物的开发。传统医学数据的系统分析对于识别一致且可靠的药材至关重要。在这项研究中，我们整理并分析了 505 个处方的数据集，涵盖 567 种药材，用于治疗 106 种疾病。使用关联规则挖掘，我们确定了疾病和药材之间的显着关联。值得注意的是，伤口愈合（最常治疗的疾病）与 Rumex abyssinicus Jacq. 密切相关，显示出很高的支持价值。这种关联导致了对 R. abyssinicus Jacq 的进一步计算机和网络分析。化合物，揭示了富含各种 KEGG 途径和生物过程的 756 个治疗靶点。应用于 CODA PPI 网络的随机行走与重启 (RWR) 算法识别出这些目标与癌症、炎症以及代谢、免疫、呼吸和神经系统疾病等疾病有关。 PPI 网络中的许多中心靶基因也与伤口愈合直接相关，支持 R. abyssinicus Jacq 的传统用途。用于治疗伤口。总之，本研究揭示了埃塞俄比亚传统医学中疾病与药材之间的重要关联，强调了R. abyssinicus Jacq 的治疗潜力。这些发现为进一步研究（包括体外和体内研究）奠定了基础，以探索和验证传统和天然产品衍生药物的功效。© 2024。作者。

Multicomponent traditional medicine prescriptions are widely used in Ethiopia for disease treatment. However, inconsistencies across practitioners, cultures, and locations have hindered the development of reliable therapeutic medicines. Systematic analysis of traditional medicine data is crucial for identifying consistent and reliable medicinal materials. In this study, we compiled and analyzed a dataset of 505 prescriptions, encompassing 567 medicinal materials used for treating 106 diseases. Using association rule mining, we identified significant associations between diseases and medicinal materials. Notably, wound healing-the most frequently treated condition-was strongly associated with Rumex abyssinicus Jacq., showing a high support value. This association led to further in silico and network analysis of R. abyssinicus Jacq. compounds, revealing 756 therapeutic targets enriched in various KEGG pathways and biological processes. The Random-Walk with Restart (RWR) algorithm applied to the CODA PPI network identified these targets as linked to diseases such as cancer, inflammation, and metabolic, immune, respiratory, and neurological disorders. Many hub target genes from the PPI network were also directly associated with wound healing, supporting the traditional use of R. abyssinicus Jacq. for treating wounds. In conclusion, this study uncovers significant associations between diseases and medicinal materials in Ethiopian traditional medicine, emphasizing the therapeutic potential of R. abyssinicus Jacq. These findings provide a foundation for further research, including in vitro and in vivo studies, to explore and validate the efficacy of traditional and natural product-derived medicines.© 2024. The Author(s).