阿司匹林但他汀类药物与胃癌成反比，并具有持续风险的影响：胃癌集合的结果
Aspirin but not statins is inversely related to gastric cancer with a duration-risk effect: Results from the Stomach Cancer Pooling Project Consortium
影响因子:5.10000
分区:医学1区 Top / 肿瘤学2区
发表日期:2024 Dec 15
作者:
Roberta Pastorino, Denise Pires Marafon, Michele Sassano, Ilda Hoxhaj, Claudio Pelucchi, Linda M Liao, Charles S Rabkin, Rashmi Sinha, Nuno Lunet, Samantha Morais, David Zaridze, Dmitry Maximovich, Nuria Aragonés, Gemma Castaño-Vinyals, Inés Gómez-Acebo, Lizbeth López-Carrillo, Malaquias López-Cervantes, Rossella Bonzi, Federica Turati, Paolo Boffetta, Maria Constanza Camargo, Maria Paula Curado, Jesus Vioque, Zuo-Feng Zhang, Eva Negri, Carlo La Vecchia, Stefania Boccia
摘要
尽管先前的研究结果不一致，但已建议阿司匹林和他汀类药物对胃癌具有潜在的化学预防作用（GC）。因此，这项研究旨在研究阿司匹林和他汀类药物的使用与GC之间的关联。对胃癌汇集项目中的七项病例对照研究进行了汇总分析，包括3220例病例和9752例对照。调整了潜在的混杂因素后，使用了两阶段的建模分析来估计阿司匹林和他汀类药物使用和GC之间的关联。阿司匹林使用者的GC的汇总比值比（OR）与非使用者的汇总比率为0.72（95％置信区间[CI]，0.54-0.95）。在没有GC家族史的个体中，阿司匹林的保护作用似乎更强（OR，0.60; 95％CI，0.37-0.95），尽管在有和没有家族史的人之间存在边界异质性（P = .064）。 GC的OR随着阿司匹林使用持续时间的增加而降低，持续时间为≥15岁，为0.41（95％CI，0.18-0.95）。观察到与单独使用他汀类药物的使用的逆，非显着的关联（OR，0.79; 95％CI，0.52-1.18）。这些发现表明，阿司匹林使用，尤其是长期使用，与GC的风险降低有关，而与Statins相似的相似性，可能是由于使用量低的可能性。
Abstract
Aspirin and statins have been suggested to have potential chemopreventive effects against gastric cancer (GC), although the results of previous studies have been inconsistent. This study therefore aimed to investigate the association between the use of aspirin and statins and GC.A pooled analysis of seven case-control studies within the Stomach Cancer Pooling Project, including 3220 cases and 9752 controls, was conducted. Two-stage modeling analyses were used to estimate the association between aspirin and statin use and GC after adjusting for potential confounders.The pooled odds ratio (OR) of GC for aspirin users versus nonusers was 0.72 (95% confidence interval [CI], 0.54-0.95). The protective effect of aspirin appeared stronger in individuals without a GC family history (OR, 0.60; 95% CI, 0.37-0.95), albeit with borderline heterogeneity between those with and without a family history (p = .064). The OR of GC decreased with increasing duration of aspirin use, with an OR of 0.41 (95% CI, 0.18-0.95) for durations of ≥15 years. An inverse, nonsignificant association with the risk of GC was observed for the use of statins alone (OR, 0.79; 95% CI, 0.52-1.18).These findings suggest that aspirin use, particularly long-term use, is associated with a reduced risk of GC, whereas a similar association was not observed with statins, possibly because of the low frequency of use.