美国最大国家肿瘤登记处中的新发乳腺癌病例比较研究

Comparison of incident breast cancer cases in the largest national US tumor registries

CANCER

影响因子:5.1

分区:医学1区 Top / 肿瘤学2区

发表日期:2025 Jan 01

作者: Jennifer K Plichta, Samantha M Thomas, Tori C Chanenchuk, Kelley Chan, Terry Hyslop, E Shelley Hwang, Rachel A Greenup

DOI: 10.1002/cncr.35525

摘要

本研究比较了国家癌症数据库（NCDB）和监测、流行病学及终末结果计划（SEER）中的新发乳腺癌（BC）病例，与全国癌症统计（USCS）进行对比。分析对象为2010-2019年在NCDB和SEER中诊断的恶性或原位乳腺癌患者。通过将NCDB和SEER中的病例数占USCS病例总数的比例，估算病例覆盖率。结果显示，USCS报告了3,047,509例患者；其中77.5%的患者被NCDB纳入，46.0%的患者被SEER纳入。不同性别患者的病例识别存在显著差异（p < 0.001）。男性患者中，84.1%被NCDB覆盖，而女性患者中此比例为77.5%。SEER中，女性的病例覆盖率优于男性（46.1%对比43.5%）。不同种族/族裔的病例覆盖率也存在显著差异（p < 0.001）。在NCDB中，非西班牙裔白人（78.2%）、非西班牙裔黑人（77.7%）和非西班牙裔亚裔或太平洋岛民（72.5%）乳腺癌患者的病例覆盖率最高，西班牙裔则最低（56.4%），非西班牙裔美洲原住民/阿拉斯加原住民最低（41.1%）。在SEER中，亚裔或太平洋岛民（78.1%）和西班牙裔的病例覆盖率最高（69.6%），而其他亚组（非西班牙裔黑人44.8%、非西班牙裔白人42.4%、非西班牙裔美洲原住民/阿拉斯加原住民36.6%）则显著偏低。国家级肿瘤登记提供了大量乳腺癌患者数据，但在年龄、性别和种族/族裔方面存在显著差异。这提示在使用这些数据进行分析和解读时应考虑这些差异性。

Abstract

This study compared incident breast cancer cases in the National Cancer Database (NCDB) and Surveillance, Epidemiology, End Results Program (SEER) to a national population cancer registry.Patients with malignant or in situ breast cancer (BC) 2010-2019 in the NCDB and SEER were compared to the US Cancer Statistics (USCS). Case coverage was estimated as the number of patients in the NCDB/SEER as a proportion of USCS cases.The USCS reported 3,047,509 patients; 77.5% patients were included in the NCDB and 46.0% in SEER. Case ascertainment varied significantly by patient sex (both registries, p < .001). For males, 84.1% were captured in the NCDB, whereas only 77.5% of females were included. Case coverage in SEER was better for females than males (46.1% vs. 43.5%). Registries varied significantly by race/ethnicity (both p < .001). Case coverage in the NCDB was highest for non-Hispanic White (78.2%), non-Hispanic Black (77.7%), and non-Hispanic Asian or Pacific Islander (72.5%) BC patients, and lowest for Hispanic (56.4%) and non-Hispanic American Indian/Alaska Native (41.1%) patients. In SEER, case coverage was highest for non-Hispanic Asian or Pacific Islander (78.1%) and Hispanic (69.6%) patients and it was significantly lower for all other subgroups (non-Hispanic Black, 44.8%; non-Hispanic White, 42.4%; and non-Hispanic American Indian/Alaska Native, 36.6%).National US tumor registries provide data for a large sampling of breast cancer patients, yet significant differences in case coverage were observed based on age, sex, and race/ethnicity. These findings suggest that analyses using these data sets and interpretation of findings should account for these meaningful variances.