本研究将国家癌症数据库 (NCDB) 和监测、流行病学、最终结果计划 (SEER) 中的乳腺癌病例与国家人口癌症登记处进行了比较。2010-2019 年 NCDB 中的恶性或原位乳腺癌 (BC) 患者和 SEER 与美国癌症统计数据 (USCS) 进行比较。病例覆盖率按 NCDB/SEER 中的患者数量占 USCS 病例的比例进行估计。USCS 报告了 3,047,509 名患者； 77.5% 的患者被纳入 NCDB，46.0% 的患者被纳入 SEER。病例确定因患者性别而异（两个登记处，p < .001）。 NCDB 中捕获了 84.1% 的男性，而仅包括 77.5% 的女性。 SEER 中女性的病例覆盖率高于男性（46.1% vs. 43.5%）。登记情况因​​种族/族裔而异（均 p < .001）。 NCDB 的病例覆盖率最高的是非西班牙裔白人 (78.2%)、非西班牙裔黑人 (77.7%) 和非西班牙裔亚裔或太平洋岛民 (72.5%) BC 患者，最低的是西班牙裔 (56.4%) 和非西班牙裔美洲印第安人/阿拉斯加原住民 (41.1%) 患者。在 SEER 中，非西班牙裔亚裔或太平洋岛民 (78.1%) 和西班牙裔 (69.6%) 患者的病例覆盖率最高，所有其他亚组的病例覆盖率显着较低（非西班牙裔黑人，44.8%；非西班牙裔白人，42.4%） %；非西班牙裔美洲印第安人/阿拉斯加原住民，36.6%）。美国国家肿瘤登记处提供了大量乳腺癌患者样本的数据，但根据年龄、性别和种族/民族观察到病例覆盖率存在显着差异。这些发现表明，使用这些数据集进行的分析和对结果的解释应该考虑到这些有意义的差异。© 2024 美国癌症协会。

This study compared incident breast cancer cases in the National Cancer Database (NCDB) and Surveillance, Epidemiology, End Results Program (SEER) to a national population cancer registry.Patients with malignant or in situ breast cancer (BC) 2010-2019 in the NCDB and SEER were compared to the US Cancer Statistics (USCS). Case coverage was estimated as the number of patients in the NCDB/SEER as a proportion of USCS cases.The USCS reported 3,047,509 patients; 77.5% patients were included in the NCDB and 46.0% in SEER. Case ascertainment varied significantly by patient sex (both registries, p < .001). For males, 84.1% were captured in the NCDB, whereas only 77.5% of females were included. Case coverage in SEER was better for females than males (46.1% vs. 43.5%). Registries varied significantly by race/ethnicity (both p < .001). Case coverage in the NCDB was highest for non-Hispanic White (78.2%), non-Hispanic Black (77.7%), and non-Hispanic Asian or Pacific Islander (72.5%) BC patients, and lowest for Hispanic (56.4%) and non-Hispanic American Indian/Alaska Native (41.1%) patients. In SEER, case coverage was highest for non-Hispanic Asian or Pacific Islander (78.1%) and Hispanic (69.6%) patients and it was significantly lower for all other subgroups (non-Hispanic Black, 44.8%; non-Hispanic White, 42.4%; and non-Hispanic American Indian/Alaska Native, 36.6%).National US tumor registries provide data for a large sampling of breast cancer patients, yet significant differences in case coverage were observed based on age, sex, and race/ethnicity. These findings suggest that analyses using these data sets and interpretation of findings should account for these meaningful variances.© 2024 American Cancer Society.