多项研究报道了LIN28A基因多态性（rs3811463 T > C和rs34787247 G > A）与癌症易感性之间的关系，但结果不一致，需要进一步阐明。本研究旨在评估它们的关系，并探讨泛癌中LIN28A基因表达与免疫浸润、肿瘤分期、生存预后和药物敏感性之间的关系。荟萃分析和数据挖掘分别由STATA软件和GSCA平台完成。 Meta分析显示，rs3811463多态性与中国人群癌症易感性无关，而rs34787247多态性与中国人群癌症易感性相关[AA vs. GG：比值比（OR）=1.98，95%置信区间（CI） =1.35-2.89，PZ<0.001； GA 与 GG：OR = 1.17，95%CI= 1.01-1.36，PZ=0.04； (AA  GA) 与 GG：OR = 1.24，95%CI = 1.07-1.43，PZ=0.004； AA 与 (GA  GG)：OR = 1.90，95%CI = 1.30-2.78，PZ=0.001； A 与 G：OR = 1.27，95%CI = 1.12-1.44，PZ<0.001]。 LIN28A基因表达不仅与某些癌症的免疫浸润、病理分期和生存预后相关，而且与多种抗癌药物（如顺铂、帕唑帕尼、奥拉帕尼和塞美替尼）的敏感性相关。总之，本研究表明rs34787247 G > A多态性可能作为中国人群的癌症风险标记，而LIN28A可能作为某些癌症的预后标记和治疗靶点。

Several studies have reported the relationship between LIN28A gene polymorphisms (rs3811463 T > C and rs34787247 G > A) and cancer susceptibility, but the results are inconsistent and need further clarification. The current study aimed to evaluate their relationship and also to explore the relationship between LIN28A gene expression and immune infiltration, tumor stage, survival prognosis, and drug sensitivity in pan-cancer. The meta-analysis and data mining were completed by STATA software and the GSCA platform, respectively. The meta-analysis showed that the rs3811463 polymorphism was not associated with cancer susceptibility, while the rs34787247 polymorphism was associated with cancer susceptibility in the Chinese population [AA vs. GG: Odd Ratio (OR)=1.98, 95% Confidence Interval (CI)=1.35-2.89, PZ<0.001; GA vs. GG: OR = 1.17, 95%CI= 1.01-1.36, PZ=0.04; (AA + GA) vs. GG: OR = 1.24, 95%CI = 1.07-1.43, PZ=0.004; AA vs. (GA + GG): OR = 1.90, 95%CI = 1.30- 2.78, PZ=0.001; A vs. G: OR = 1.27, 95%CI = 1.12-1.44, PZ<0.001]. LIN28A gene expression was associated not only with immune infiltration, pathological stage, and survival prognosis of certain cancers, but also with sensitivity to multiple anticancer drugs, such as cisplatin, pazopanib, olaparib, and selumetinib. In conclusion, the current study suggested that the rs34787247 G > A polymorphism might be used as a cancer risk marker in the Chinese population, and LIN28A might serve as a prognostic marker and therapeutic target for certain cancers.