本研究旨在通过使用集成 SPECT/CT 扫描仪对正常脊柱和骨盆中 99mTc-MDP 的 SUV 进行定量测量和比较各种标准化方法，以确定相对稳健的 SUV，以指导临床实践。 2017 年 6 月至 2019 年 9 月共有 500 名接受 99mTc-MDP 骨 SPECT/CT 扫描的肿瘤患者（平均年龄 60.9 岁；男性 66.0%）参加了这项回顾性研究。根据患者体重 (BW)、去脂体重 (LBM)、骨矿物质含量 (BMC)、体表面积 (BSA) 和体重指数计算 4962 块脊柱和骨盆骨的平均 SUV (SUVmean) (BMI)，分别定义为 SUVbw、SUVlbm、SUVbmc、SUVbsa 和 SUVbmi。比较上述参数的变异系数（COV），并利用相关性和多元线性回归分析来比较这些参数受性别、年龄、身高、体重、BMI和CT值影响的程度。正常脊柱和骨盆的平均SUV表现出相对较大的变异性：SUVbw为4.573±1.972，SUVlbm为3.555±1.517，SUVbmc为0.163±0.071，SUVbsa为0.124±0.052，SUVbsa为1.668 SUVbmi 为 ± 0.732。总体而言，与其他 SUV 相比，SUVbsa 在所有椎骨和骨盆中的 CoV 相对最低（42.1%）。对于相关性分析，所有 SUV 均与年龄和 CT 值呈现微弱但显着的相关性。对于回归分析，SUVbsa 仅受年龄、BMI 和 CT 值的独立影响。这些变量对SUVbsa的影响均小于对常规SUVbw的影响。定量骨SPECT/CT得出的正常骨中99mTc-MDP的SUV可作为评估肿瘤骨转移的参考，但应根据特定地点的基础。 SUVbsa 在所有 SUV 归一化变化中表现出卓越的稳健性，表明潜在的临床应用。© 2024。作者获得日本核医学会的独家许可。

This study aimed to identify a relatively robust SUV for guiding clinical practice through quantitative measurement and comparison of various normalization methods based on the SUV of 99mTc-MDP in the normal spine and pelvis using an integrated SPECT/CT scanner.Between June 2017 and September 2019, a total of 500 oncology patients (mean age, 60.9; men, 66.0%) who underwent bone SPECT/CT scans with 99mTc-MDP were enrolled in this retrospective study. The mean SUV (SUVmean) of 4962 spinal and pelvic bones was calculated based on the patients' body weight (BW), lean body mass (LBM), bone mineral content (BMC), body surface area (BSA), and body mass index (BMI), defined as SUVbw, SUVlbm, SUVbmc, SUVbsa, and SUVbmi, respectively. The coefficients of variation (CoVs) of the aforementioned parameters were compared, and the correlation and multiple linear regression analyses were used to compare the extent to which these parameters were affected by sex, age, height, weight, BMI, and CT values.The average SUVs in the normal spine and pelvis displayed a relatively wide variability: 4.573 ± 1.972 for SUVbw, 3.555 ± 1.517 for SUVlbm, 0.163 ± 0.071 for SUVbmc, 0.124 ± 0.052 for SUVbsa, and 1.668 ± 0.732 for SUVbmi. In general, SUVbsa had relatively lowest CoV (42.1%) in all vertebrae and pelvis compared with other SUVs. For correlation analyses, all SUVs displayed weak but significant correlations with age and CT values. For regression analyses, SUVbsa was influenced only by age, BMI, and CT values independently. The effects of these variables on SUVbsa were all smaller than those on conventional SUVbw.The SUVs of 99mTc-MDP in normal bone derived from quantitative bone SPECT/CT could serve as a reference for evaluating tumor bone metastasis, but it should be assessed on a site-specific basis. SUVbsa exhibited superior robustness among all the SUV normalization variations, indicating potential clinical applications.© 2024. The Author(s) under exclusive licence to The Japanese Society of Nuclear Medicine.