环境空气污染可能是卵巢癌 (OC) 生存的预后因素，但植物性饮食指数 (PDI) 与 OC 生存之间的关系仍不清楚。我们的目的是调查综合空气污染和 PDI 与 OC 生存的关系，并探讨空气污染与饮食相互作用的影响。本研究涵盖了 658 名诊断为 OC 的患者。通过自我报告的经过验证的食物频率调查问卷评估总体植物性饮食指数 (PDI)、健康 PDI (hPDI) 和不健康 PDI (uPDI)。此外，空气污染评分（APS）是通过将直径2.5微米以下的颗粒物、臭氧和二氧化氮的浓度相加得出的。应用 Cox 比例风险模型来计算风险比 (HR) 和 95% 置信区间 (CI)。在乘法和加法尺度上评估了 APS 与 PDI 与总生存期 (OS) 相关的潜在相互作用。在中位随访 37.60 个月（四分位间距：24.77-50.70）个月中，确认了 123 例死亡。与最低三分位数相比，最高 uPDI 与较低的 OC 总生存期相关（HR = 2.06，95% CI = 1.30, 3.28；P 趋势 < 0.01），而总体 PDI 或 hPDI 与 OC 生存率之间未发现显着关联。较高的 APS（每四分位数范围的 HR = 1.27，95% CI = 1.01，1.60）与较差的 OC 生存率显着相关，并且坚持 uPDI 会加剧这种关联。值得注意的是，联合空气污染和 uPDI 之间存在相加相互作用（对于高 APS 和高 uPDI，P < 0.005）。我们还发现，坚持总体 PDI 加剧了空气污染与 OC 存活率的关联（P 交互作用 = 0.006）。共同暴露于各种环境空气污染物与 OC 患者的较低存活率显着相关，特别是对于那些主要食用不健康植物的患者基于食品。版权所有 © 2024 作者。由爱思唯尔公司出版。保留所有权利。

Ambient air pollution might serve as a prognostic factor for ovarian cancer (OC) survival, yet the relationships between plant-based diet indices (PDIs) and OC survival remain unclear. We aimed to investigate the associations of comprehensive air pollution and PDIs with OC survival and explored the effects of air pollution-diet interactions.The present study encompassed 658 patients diagnosed with OC. The overall plant-based diet index (PDI), the healthful PDI (hPDI), and the unhealthful PDI (uPDI) were evaluated by a self-reported validated food frequency questionnaire. In addition, an air pollution score (APS) was formulated by summing the concentrations of particulate matter with a diameter of 2.5 microns or less, ozone, and nitrogen dioxide. Cox proportional hazard models were applied to calculate hazard ratios (HRs) and 95 % confidence intervals (CIs). The potential interactions of APS with PDIs in relation to overall survival (OS) were assessed on both multiplicative and additive scales.Throughout a median follow-up of 37.60 (interquartile: 24.77-50.70) months, 123 deaths were confirmed. Comparing to the lowest tertiles, highest uPDI was associated with lower OS of OC (HR = 2.06, 95 % CI = 1.30, 3.28; P-trend < 0.01), whereas no significant associations were found between either overall PDI or hPDI and OC survival. Higher APS (HR for per interquartile range = 1.27, 95 % CI = 1.01, 1.60) was significantly associated with worse OC survival, and the association was exacerbated by adherence to uPDI. Notably, an additive interaction was identified between combined air pollution and uPDI (P < 0.005 for high APS and high uPDI). We also found that adherence to overall PDI aggravated associations of air pollution with OC survival (P-interaction = 0.006).Joint exposure to various ambient air pollutants was significantly associated with lower survival among patients with OC, particularly for those who predominantly consumed unhealthy plant-based foods.Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.