结肠癌（CC）是与胃肠系统相关的最常见恶性肿瘤之一，其发病率和死亡率在世界各地都有报道不断增加。对抗CC等癌症的标准治疗方法包括手术方法、化疗和放疗，这些治疗方法是临床医生根据患者的病情和疾病阶段建议的。然而，使用这些方式的患者可能会遭受严重的副作用和不良后果，例如毒性和肿瘤复发，以及较低的 5 年生存率。目前的大量证据表明，间充质干细胞（MSC）具有治疗不同健康问题，尤其是肿瘤的适当能力。这些多能干细胞可以从多种来源分离，例如脐带、骨髓、脂肪组织和胎盘。在这些间充质来源中，脐带间充质干细胞因其具有免疫原性低、无伦理问题、易于采集等优点而受到科学界的广泛关注。如今，人们已经探索了脐带间充质干细胞和基于脐带间充质干细胞的策略（例如条件培养基、细胞外囊泡和外泌体）对 CC 的功效，并提出了有希望的发现。因此，在这篇综述中，我们旨在总结和辩论关于 UC-MSC 及其相关产品对 CC 的影响的证据，重点关注其治疗和发病机制中涉及的分子和细胞机制。版权所有 © 2024 Elsevier Ltd 。 版权所有。

Colon cancer (CC) stands as one of the most common malignancies related to the gastrointestinal system, whose increasing incidence and death rates have been reported all over the world. Standard treatments for fighting cancers like CC comprise surgical approaches, chemotherapy, and radiotherapy, which are suggested by clinicians according to patients' conditions and disease stages. However, patients who utilize these modalities may suffer from serious side effects and adverse outcomes, for example, toxicity and tumor recurrence, as well as a low 5-year survival rate. The present shreds of evidence showed that mesenchymal stem cells (MSCs) can have a suitable capacity for treating different health problems, especially neoplasms. These multipotent stem cells can be isolated from several sources, such as the umbilical cord, bone marrow, adipose tissue, and placenta. Among these mesenchymal sources, umbilical cord-MSCs have gathered much attention in scientific societies due to their advantages (e.g., low immunogenicity, lack of ethical problems, and easy collection). These days, the efficacy of umbilical cord-MSCs and umbilical cord-MSCs-based strategies, such as conditioned medium, extracellular vesicles, and exosomes, on CC have been explored, and promising findings have been stated. Therefore, in this review, we aimed to summarize and debate evidence regarding the effects of UC-MSCs and their related products on CC with a focus on molecular and cellular mechanisms involved in its treatment and pathogenesis of this malignant tumor.Copyright © 2024 Elsevier Ltd. All rights reserved.