金属酚网络(MPNs)是近年来逐渐发展起来的一类新型纳米材料，由金属离子和多酚配体自组装而成。 MPNs由于其环保性、良好的粘附性以及与绿色酚类配体的生物相容性，可作为一种新型纳米材料。它们表现出抗炎、抗氧化、抗菌、抗癌等优异特性，在生物医学领域得到了广泛的研究。作为MPNs家族中最常见的亚类之一，铜基MPNs已被广泛研究用于药物递送、光动力疗法（PDT）、化疗动力疗法（CDT）、抗菌抗炎、骨组织再生、皮肤再生伤口修复和金属离子成像。本文综述了不同类型铜基 MPN 的制备策略。然后详细介绍了不同多酚配体下铜基MPNs在生物医学领域的应用现状。最后讨论了铜基 MPN 存在的问题和挑战，以及其在生物医学领域的未来应用前景。版权所有 © 2024 Elsevier B.V. 保留所有权利。

Metal-phenolic Networks (MPNs) are a novel class of nanomaterial developed gradually in recent years which are self-assembled by metal ions and polyphenolic ligands. Due to their environmental protection, good adhesion, and biocompatibility with green phenolic ligands, MPNs can be used as a new type of nanomaterial. They show excellent properties such as anti-inflammatory, antioxidant, antibacterial, and anticancer, and have been widely studied in the biomedical field. As one of the most common subclasses of the MPNs family, copper-based MPNs have been widely studied for drug delivery, Photodynamic Therapy (PDT), Chemo dynamic Therapy (CDT), antibacterial and anti-inflammatory, bone tissue regeneration, skin regeneration wound repair, and metal ion imaging. In this paper, the preparation strategies of different types of copper-based MPNs are reviewed. Then, the application status of copper-based MPNs in the biomedical field under different polyphenol ligands is introduced in detail. Finally, the existing problems and challenges of copper-based MPNs are discussed, as well as their future application prospects in the biomedical field.Copyright © 2024 Elsevier B.V. All rights reserved.