胃肠道 (GI) 癌症继续构成重大的全球健康挑战。我们对宿主和肠道微生物群之间复杂关系的理解的最新进展揭示了代谢相互作用在胃肠道癌症发病机制和进展中的关键作用。在这项研究中，我们研究了微生物群如何与宿主相互作用，从而影响影响胃肠道肿瘤形成的信号通路。此外，我们还研究了在临床环境中操纵胃肠道微生物群的潜在治疗方法。揭示宿主和肠道微生物群之间复杂的分子交换有助于更深入地了解驱动癌症发展的潜在机制。代谢相互作用有望识别与癌症特定阶段相关的微生物特征或代谢途径。因此，这项研究为胃肠道癌症的诊断、治疗和管理提供了潜在的策略，以改善患者的治疗结果。版权所有 © 2024 作者。由 Elsevier B.V. 出版。保留所有权利。

Gastrointestinal (GI) cancer continues to pose a significant global health challenge. Recent advances in our understanding of the complex relationship between the host and gut microbiota have shed light on the critical role of metabolic interactions in the pathogenesis and progression of GI cancer. In this study, we examined how microbiota interact with the host to influence signalling pathways that impact the formation of GI tumours. Additionally, we investigated the potential therapeutic approach of manipulating GI microbiota for use in clinical settings. Revealing the complex molecular exchanges between the host and gut microbiota facilitates a deeper understanding of the underlying mechanisms that drive cancer development. Metabolic interactions hold promise for the identification of microbial signatures or metabolic pathways associated with specific stages of cancer. Hence, this study provides potential strategies for the diagnosis, treatment and management of GI cancers to improve patient outcomes.Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.