脂肪酸代谢是一个复杂的生化过程，包括脂肪酸的产生、分解和应用。脂肪酸代谢不仅是脂质代谢的重要组成部分，还与细胞的能量代谢途径相关，对维持生物体的能量平衡起着至关重要的作用。二酰基甘油-O-酰基转移酶 1 (DGAT1) 和二酰基甘油-O-酰基转移酶 2 (DGAT2) 是调节脂质代谢的关键成分，为细胞增殖和生长提供能量。最近的研究表明，DGAT1 和 DGAT2 通过癌症中的脂肪酸代谢影响肿瘤进展。尽管DGAT1和DGAT2具有相似的名称，但它们在各个方面存在显着差异，并且在个体肿瘤中发挥不同的作用。对这些酶的生理作用及其在不同类型肿瘤中的差异表达进行比较分析将增强我们对其独特特征的理解。本文总结了肿瘤脂肪酸代谢的特点，并解释了DGAT1和DGAT2如何特异性促进肿瘤进展。此外，该综述讨论了降脂药物在肿瘤治疗中的潜力，为未来靶向脂肪酸代谢抑制肿瘤进展提供了新的视角，同时强调了DGAT1和DGAT2作为肿瘤治疗潜在靶点的重要性。 © 2024。由 Elsevier B.V. 出版

Fatty acid metabolism is a complex biochemical process, including the production, breakdown and application of fatty acids. Not only is it an important component of lipid metabolism, fatty acid metabolism is also connected to the energy metabolism pathways of cells and plays a vital role in maintaining the energy balance of organisms. Diacylglycerol-O-acyltransferase 1 (DGAT1) and Diacylglycerol-O-acyltransferase 2 (DGAT2) are key components in regulating lipid metabolism, which provide energy for cell proliferation and growth. Recent studies have shown that DGAT1 and DGAT2 influence tumor progression through fatty acid metabolism in cancer. Although DGAT1 and DGAT2 have similar names, they differ significantly in various aspects and play distinct roles in individual tumors. A comparative analysis of the physiological roles of these enzymes and their differential expressions in different types of tumors will enhance our understanding of their unique characteristics. This article summarizes the characteristics of tumor fatty acid metabolism and explains how DGAT1 and DGAT2 specifically promote tumor progression. In addition, this review discusses the potential of lipid-lowering drugs in tumor treatment, providing a new perspective on targeting fatty acid metabolism to inhibit tumor progression in the future, while emphasizing the importance of DGAT1 and DGAT2 as potential targets for tumor treatment.Copyright © 2024. Published by Elsevier B.V.