miRNA 是短的非编码 RNA 分子，已被证明可以在转录后水平影响大量基因，从而调节多个信号通路。由于 miRNA-34 家族调节许多不同的信号通路，包括与癌症、免疫系统、新陈代谢、细胞结构和神经系统疾病相关的信号通路，因此它引起了研究人员的极大关注。 miRNA-34 家族的成员已被证明可以抑制多种癌症类型的肿瘤。该家族对于肥胖、心血管系统和糖酵解也很重要。有趣的是，已知 miRNA-34 家族在重度抑郁症、精神分裂症、帕金森病 (PD)、不良童年经历或创伤、压力反应调节、阿尔茨海默病 (AD) 和压力相关疾病中发挥作用。精神状况。在这篇综述中，miRNA-34 家族的预期靶标与通过通路分析确定的既定靶标一起呈现。此外，还将讨论该 miRNA 家族的治疗潜力。版权所有 © 2024 Elsevier B.V. 保留所有权利。

MiRNAs are short non-coding RNA molecules that have been shown to affect a vast number of genes at the post-transcriptional level, hence regulating several signaling pathways. Because the miRNA-34 family regulates a number of different signaling pathways, including those linked to cancer, the immune system, metabolism, cellular structure, and neurological disorders, it has garnered a great deal of attention from researchers. Members of the miRNA-34 family have been shown to inhibit tumors in a variety of cancer types. This family is also important for obesity, the cardiovascular system, and glycolysis. It's interesting to note that the miRNA-34 family is known to play a role in major depressive disorder, schizophrenia, Parkinson's disease (PD), adverse childhood experiences or trauma, regulation of stress responses, Alzheimer's disease (AD), and stress-related psychatric conditions. In this review, the expected targets of the miRNA-34 family are presented alongside the well-established targets identified by pathway analysis. Furthermore, the therapeutic potential of this miRNA family will be discussed.Copyright © 2024 Elsevier B.V. All rights reserved.