胃肠血管发育不良（GIAD）在普通人群中是一种罕见的诊断。我们的目的是确定 GIAD 的危险因素并确定一般人群中的发生率。进行了一项基于人群的回顾性研究，包括根据诊断代码诊断为上段（胃/十二指肠）或下段（小肠/结肠）GIAD 的患者来自大型健康维护组织。对照组的年龄和性别相匹配。收集了包括人口统计、合并症、恶性肿瘤和药物在内的其他数据。纳入了 991 名高 GIAD 和 3336 名低 GIAD，而对照组为 7217 名和 32,802 名。 GIAD 的总体患病率为 0.092%。 88% 的高位 GIAD 和 85% 的低位 GIAD 在 60 岁以上时被诊断出来，71-80 岁的患病率达到峰值，为 0.37%。 GIAD 最显着的危险因素包括肝硬化（下 GIAD 为 OR 4.0，上 GIAD 为 OR 7.0，p < 0.001）、高血压（下 GIAD 为 OR 2.3，上 GIAD 为 OR 2.8，p < 0.001）和主动脉瓣狭窄（对于较低 GIAD 为 OR 2.8，对于较高 GIAD 为 OR 2.0，p < 0.001）。其他重要的危险因素包括缺血性心脏病、慢性肾功能衰竭、女性和慢性阻塞性肺病。有趣的是，发现恶性肿瘤患者中上、下 GIAD 的发生率均显着降低。确定与 GIAD 相关的临床状况和人口统计学因素可能会提高我们对这种罕见疾病的病因和最佳治疗方式的理解。版权所有 © 2024 Editrice Gastroenterologica Italiana S.r.l.由爱思唯尔有限公司出版。保留所有权利。

Gastrointestinal angiodysplasia (GIAD) is a rare diagnosis among the general population. We aimed to identify risk factors for GIADs and to determine the frequency rate in the general population.A population-based retrospective study was performed including patients diagnosed with upper (stomach/duodenum) or lower (small bowel/colon) GIADs based on diagnostic codes from a large health maintenance organization. Control groups were matched for age and gender. Additional data including demographics, comorbidities, malignancies, and medications were collected.991 upper GIADs and 3336 lower GIADs were included, compared to 7217 and 32,802 controls. The overall prevalence of GIAD was 0.092 %. 88 % of the upper and 85 % of the lower GIADs were diagnosed at ages ≥60, peaking at a prevalence of 0.37 % for ages 71-80. The most significant risk factors for GIADs included liver cirrhosis (OR 4.0 for lower GIAD and OR 7.0 for upper GIAD, p < 0.001), hypertension (OR 2.3 for lower GIAD and OR 2.8 for upper GIAD, p < 0.001) and aortic stenosis (OR 2.8 for lower GIAD and OR 2.0 for upper GIAD, p < 0.001). Other significant risk factors included ischemic heart disease, chronic renal failure, female gender, and chronic obstructive pulmonary disease. Interestingly, both upper and lower GIADs were found to be significantly less frequent in patients with malignancy.Identification of the clinical conditions and demographic factors associated with GIAD may improve our understanding of the etiology and the optimal treatment modalities for this rare condition.Copyright © 2024 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.